中国药房2017，Vol.28Issue(20)：2771-2774,4.DOI:10.6039/j.issn.1001-0408.2017.20.10
我院耐碳青霉烯类革兰氏阴性杆菌检出率与药物消耗量的相关性分析
Correlation Analysis of the Detection Rate of Carbapenems-resistant Gram-negative Bacillus with Drug Consumption in Our Hospital
徐永祥 1刘治安 1黄惠英 1姚国新 1汤远亮1
作者信息
- 1. 东莞东华医院药学部,广东东莞 523110
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for standardizing the clinical use of carbapenem antibiotics and controlling drug-resistant bacteria infection. METHODS:The detection of 3 kinds of carbapenems-resistant Gram-negative bacillus in our hospi-tal during 2011-2016 were analyzed retrospectively. The consumption,target cure rate and treatment course of carbapenem antibiot-ics were analyzed statistically. The correlation between detection rate of drug-resistant bacteria with the consumption of carbapenem antibiotics was investigated by Pearson test. RESULTS:During 2011-2016,1222 strains of carbapenems-resistant Acinetobacter bauman (CRAB),655 strains of carbapenems-resistant Pseudomonas aeruginosa (CRPA) and 53 strains of carbapenem-resistant Escherichia coli (CRE) were detected in our hospital. The detection rates increased from 23.88%,8.92%,0.09% in 2011 to 80.34%,35.74%,0.97% in 2016. The types of carbapenem antibiotics in our hospital were mainly imipenem and meropenem. The consumption of them increased from 4222,145 g in 2011 to 7218,4387 g in 2016. The both target cure rates were all lower than 60%,and the proportion of the patients with treatment course >14 d was more than 65%. The detection rates of CRAB,CR-PA and CRE were positively correlated with the consumption of carbapenem antibiotics (r>0.9,P<0.05). CONCLUSIONS:The detection rate of carbapenems-resistant Gram-negative bacillus and drug consumption increase year by year in our hospital,and they have certain correlation. The target cure rate of carbapenem antibiotics in our hospital is in low level,and there is a long treatment course. They are should be standardized in the clinic. The selection of carbapenem antibiotics should be strictly followed clinical in-dications so as to reduce the generation of drug-resistant strains.关键词
耐碳青霉烯类/革兰氏阴性杆菌/检出率/消耗量/相关性Key words
Carbapenems-resistant/Gram-negative bacillus/Detection rate/Consumption/Correlation分类
医药卫生引用本文复制引用
徐永祥,刘治安,黄惠英,姚国新,汤远亮..我院耐碳青霉烯类革兰氏阴性杆菌检出率与药物消耗量的相关性分析[J].中国药房,2017,28(20):2771-2774,4.
