中国药房2017，Vol.28Issue(20)：2790-2792,3.DOI:10.6039/j.issn.1001-0408.2017.20.15
匹多莫德治疗支气管哮喘合并反复呼吸道感染患儿的临床研究
Clinical Study on Pidotimod in the Treatment of Bronchial Asthma Complicated with Recurrent Respiratory Tract Infection in Children
摘要
Abstract
OBJECTIVE:To investigate the clinical effects of pidotimod in the bronchial asthma complicated with recurrent re-spiratory tract infection,and its effects on immunoglobulin and related indexes. METHODS:A total of 120 bronchial asthma pa-tients with recurrent respiratory tract infection selected from our hospital during Mar. 2011-May 2013 were divided into trial group and control group according to random number table,with 60 cases in each group. Control group received routine corticosteroid therapy,and trial group was additionally given Pidotimod oral solution 0.4 g,po,bid,for 14 d,on the basis of control group. Clinical indexes(the times of respiratory infection,the duration of fever,cough,wheezing attack and antibiotics use),serum in-dexes [β-defensin-1(hBD-1),immunoglobulin A(IgA),IgG,IgM,UREA,ALT],the results of pharynx test before and after treatment,and the occurrence of ADR were observed in 2 groups. RESULTS:Before treatment,there was no statistical signifi-cance in clinical indexes,serum indexes,the results of pharynx test between 2 groups(P>0.05). After treatment,clinical indexes of trial group were significantly lower or shorter then before treatment or control group,while serum levels of hBD-1,IgA and IgG were significantly higher than before treatment or control group,with statistical significance(P<0.05). There was no statistical sig-nificance in clinical indexes and serum indexes of control group,serum levels of IgM,UREA and ALT in trial group before and af-ter treatment(P>0.05). The types and number of pathogenic bacteria of respiratory tract infection were decreased significantly in 2 groups,and the trial group was significantly less then the control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Pidotimod shows good clinical effects on bronchial asthma complicated with recurrent re-spiratory tract infection,can improve immunity and reduce the types and number of pathogenic bacteria with good safety.关键词
匹多莫德/支气管哮喘/反复呼吸道感染/β-防御素1/免疫球蛋白Key words
Pidotimod/Bronchial asthma/Recurrent respiratory tract infection/β-defensin-1/Immunoglobulin分类
医药卫生引用本文复制引用
周雪梅,陆立东,黄建萍..匹多莫德治疗支气管哮喘合并反复呼吸道感染患儿的临床研究[J].中国药房,2017,28(20):2790-2792,3.基金项目
江西省营养学会科研基金资助课题(No.JS201204) （No.JS201204）
