中国药房2017，Vol.28Issue(20)：2796-2799,4.DOI:10.6039/j.issn.1001-0408.2017.20.17
静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床观察
Clinical Observation of Intravenous Drip of Alprostadil Combined with Acupuncture in the Treatment of Diabetic Foot Ulcer
摘要
Abstract
OBJECTIVE:To investigate clinical efficacy of intravenous drip of alprostadil combined with acupuncture in the treatment of diabetic foot ulcer and its effects on inflammatory factors levels and wound microvascular density. METHODS:A total of 72 patients with diabetic foot ulcer in our hospital during May 2014 to Sept. 2015 were divided into observation group and con-trol group according to random number table,with 36 cases in each group. Control group was given Alprostadil injection 10μg add-ed into 250 mL 0.9% Sodium chloride injection intravenously,qd,on the basis of routine treatment as insulin. Observation group was additionally given acupuncture therapy (Sanyinjiao,Zusanli,Fenglong,Yanglingquan,Yinlingquan and other acupuncture points),qd,on the basis of control group. Treatment courses of 2 groups lasted for 3 weeks. Clinical efficacy,wound healing time,fasting blood glucose,urine microalbumin,inflammatory factors,wound microvascular density as well as the occurrence of ADR were compared between 2 groups. RESULTS:The total response rate of observation group(91.67%)was significantly higher than that of control group(72.22%),and wound healing time was significantly shorter than control group,with statistical signifi-cance(P<0.05). Before treatment,there was no statistical significance in fasting blood glucose,urine microalbumin and inflamma-tory factors between 2 groups (P>0.05). After treatment,above indexes of 2 groups were significantly lower than before,and urine microalbumin and inflammatory factors of the observation group was significantly lower than the control group,with statisti-cal significance (P<0.05). 14,21 d after treatment,wound microvessel density of observation group was significantly higher those of control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Intrave-nous drip of Alprostadil combined with acupuncture can boost angiogenesis through mitigating inflammatory reactions,thus shorten the time of wound healing and enhance therapeutic efficacy.关键词
前列地尔/针灸/糖尿病足/溃疡/微血管密度/微循环障碍/炎症因子Key words
Alprostadil/Acupuncture/Diabetic foot/Ulcer/Microvascular density/Microcirculatory disturbance/Inflammato-ry factor分类
医药卫生引用本文复制引用
邵礼成,严文,李赞钊,黄文柱..静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床观察[J].中国药房,2017,28(20):2796-2799,4.基金项目
佛山市医学重点专科培育项目(No.Fspy3-2015027) （No.Fspy3-2015027）
