中国药房2017，Vol.28Issue(20)：2834-2837,4.DOI:10.6039/j.issn.1001-0408.2017.20.28
脉络宁注射液辅助治疗急性脑梗死的临床观察
Clinical Observation of Mailuoning Injection in Adjunctive Treatment of Acute Cerebral Infarction
尹文伟 1陈思 1裴璐 2毕堃 1陆斌 1张宏义1
作者信息
- 1. 唐山市工人医院神经外科,河北唐山 063000
- 2. 唐山市食品药品检验中心,河北唐山 063000
- 折叠
摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of Mailuoning injection in adjunctive treatment of acute cere-bral infarction. METHODS:A total of 65 patients with acute cerebral infarction selected from neurology department of our hospital were divided into control group(32 cases)and observation group(33 cases)according to random number table. Control group was given conventional treatment. Observation group was additionally given Mailuoning injection 10 mL added into 0.9% sodium chlo-ride injection 250 mL intrnrenously,ivgtt,qd,on the basis of control group. Both group were treated for 15 d. Clinical efficacy as well as serum levels of ox-LDL,BNP and MMP-9,NIHSS score before and after treatment,the occurrence of ADR were com-pared between 2 groups. RESULTS:The response rate of observation group was 90.91%,which was significantly higher than 65.63%,with statistical significance(P<0.05). Before treatment,there was no statistical significance in serum levels of ox-LDL, BNP or MMP-9,NIHSS score between 2 groups (P>0.05). After treatment,serum levels of ox-LDL,BNP and MMP-9,NIHSS score in 2 groups were all decreased significantly,and the observation group was significantly lower than the control group,with statis-tical significance (P<0.05). There was no statistical significance in incidence of ADR between 2 groups (P>0.05). CONCLU-SIONS:Mailuoning injection has significant therapeutic efficacy for acute cerebral infarction,can significantly reduce serum levels of ox-LDL,BNP and MMP-9,promotes neurological function and the recovery of patients with cerebral infarction with good safety.关键词
脉络宁注射液/急性脑梗死/氧化低密度脂蛋白/脑钠肽/基质金属蛋白酶9Key words
Mailuoning injection/Acute cerebral infarction/ox-LDL/BNP/MMP-9分类
医药卫生引用本文复制引用
尹文伟,陈思,裴璐,毕堃,陆斌,张宏义..脉络宁注射液辅助治疗急性脑梗死的临床观察[J].中国药房,2017,28(20):2834-2837,4.
