中国药理学通报2017，Vol.33Issue(8)：1037-1040,4.DOI:10.3969/j.issn.1001-1978.2017.08.001
ADAM8在恶性肿瘤转移中的作用研究进展
Role of ADAM8 in tumor metastasis
摘要
Abstract
Tumor metastasis is one of the important biological characteristics of malignant tumor,which is closely related with the prognosis of the cancer patients.High expression of ADAM8 in varieties of tumors was revealed in many recent studies,and such aberrant expression played a crucial role in regulating of tumor metastasis.Studies showed that overexpression of ADAM8 attenuated the intercellular adhesion effect,promoted tumor angiogenesis,and enhanced the degradation of ECM as well as the releasing of cytokines.Therefore,suppression of ADAM8 may lead to inhibition of tumor metastasis,which makes ADAM8 a particular attractive target as it can be used as a prognostic indicator and a potential therapeutic target of malignant tumor.A review about the relations between ADAM8 protein′s abnormal expression and tumor occurrence was discussed in this paper,also include discussion about the mechanisms of ADAM8 protein′s disorder-induced tumor formation,as well as therapeutic strategies based on ADAM8-targeted,which may provide references for follow-up research and clinical treatment.关键词
肿瘤/肿瘤转移/去整合素-金属蛋白酶8/ECM/作用机制/治疗策略Key words
tumor/tumor metastasis/a disintegrin and metalloproteinase 8/ECM/mechanisms/therapeutic strategy分类
医药卫生引用本文复制引用
贾琦,刘兆国,余苏云,陈力川,祝娉婷,陈文星,王爱云,陆茵..ADAM8在恶性肿瘤转移中的作用研究进展[J].中国药理学通报,2017,33(8):1037-1040,4.基金项目
国家自然科学基金项目资助 (No 81673725,81673648,81573859) （No 81673725,81673648,81573859）
江苏省自然科学基金资助项目(No BK2012854) （No BK2012854）
