中国药理学通报2017，Vol.33Issue(8)：1041-1045,5.DOI:10.3969/j.issn.1001-1978.2017.08.002
吗啡对P2Y12受体拮抗剂药代及药效动力学的影响
Effect of morphine on pharmacokinetics and pharmacodynamics of P2Y12 receptor antagonists
摘要
Abstract
P2Y12 receptor antagonists and morphine are often recommended in patients with acute myocardial infarction.P2Y12 receptor antagonists can rapidly and potently reduce the platelet activity and prevent future thrombotic events.Meanwhile,combined morphine is used to relieve symptoms of angina.A number of studies have confirmed that morphine can decrease plasma concentrations of clopidogrel and impair its anti-platelet activity,which may lead to poor response in clopidogrel-treated patients with acute coronary syndrome.The randomized trials in healthy volunteers and patients with acute myocardial infarction also confirmed the similar drug-drug interaction between morphine and ticagrelor or prasugrel.Although the P2Y12 receptor antagonists combined with morphine are still used for myocardial infarction patients,there are few report on the objective evaluation of this drug interaction.This review,based on the findings of experimental as well as observational and randomized clinical studies,summarizes completely the drug interactions between oral P2Y12 receptor antagonists and morphine.关键词
吗啡/P2Y12受体拮抗剂/氯吡格雷/替格瑞洛/普拉格雷/药物相互作用Key words
morphine/P2Y12 receptor antagonists/clopidogrel/ticagrelor/prasugrel/drug interaction分类
医药卫生引用本文复制引用
张严娇,李慕鹏,阳勇龙,陈小平..吗啡对P2Y12受体拮抗剂药代及药效动力学的影响[J].中国药理学通报,2017,33(8):1041-1045,5.基金项目
国家科技部"重大新药创制"科技重大专项资助项目(No 2013ZX09509107) （No 2013ZX09509107）
国家自然科学基金资助项目(No 81373489,81422052,81403018) （No 81373489,81422052,81403018）
湖南省杰出青年基金资助项目(No 13JJ1010) （No 13JJ1010）
