中国药理学通报2017，Vol.33Issue(8)：1051-1055,5.DOI:10.3969/j.issn.1001-1978.2017.08.004
趋化因子参与阿尔茨海默病的研究进展
Progress on chemokines participating in Alzheimer′s disease
摘要
Abstract
Chemokines play pleiotropic roles in the pathology of Alzheimer′s disease(AD),a chronic inflammatory disease of central nervous system.The neuropathological features of AD include neurofibrillary tangles,amyloid plaques,neuroinflammation,and neuronal synaptic loss.Chemokines are involved in the pathogenesis of AD by activating or regulating inflammatory cells or glial cells,playing dual key roles of the pro-and anti-inflammatory properties in AD.The levels of chemokines in serum,cerebrospinal fluid and brain tissue of AD patients are changed accordingly.This review summarizes the role of chemokines and their receptors in AD in the biological activities and unveils the changing rules,aiming to provide new strategies for clinical treatment of AD.关键词
阿尔茨海默病/神经炎症/趋化因子/神经原纤维缠结/淀粉样蛋白斑块/受体Key words
Alzheimer′s disease/neuroinflammation/chemokines/neurofibrillary tangles/amyloid plaques/receptors分类
医药卫生引用本文复制引用
罗飘,楚世峰,朱天碧,陈乃宏..趋化因子参与阿尔茨海默病的研究进展[J].中国药理学通报,2017,33(8):1051-1055,5.基金项目
国家自然科学基金资助项目(No 81603315,U1402221,81373997,81573640,81373551) （No 81603315,U1402221,81373997,81573640,81373551）
湖南省教育厅高校科研经费开放基金项目(No 15K091) （No 15K091）
