中国药理学通报2017，Vol.33Issue(8)：1056-1060,5.DOI:10.3969/j.issn.1001-1978.2017.08.005
miRNAs在甲基苯丙胺成瘾中的作用研究进展
The research progress on role of miRNAs in methamphetamine addiction
摘要
Abstract
The methamphetamine(METH)addiction is a compensatory adaptation of the central nervous system after the long-term exposure to METH in the molecular,cellular,neuronal loop function and brain structure.As a new type of post transcriptional regulatory molecules and regulatory factors,miRNAs are a large number of regulatory factors in the central nervous system.Studies have shown that miRNAs play an important role in the regulation of METH addiction.This paper is to review and summarize the expression features and the regulatory role of miRNAs in METH addiction,as well as the different expression of miRNAs in different tissues and organs.The aim of this paper is to provide a reference for further study on the role of miRNAs molecules in METH addiction and the discovery of new drug targets.关键词
法医毒理学/microRNAs/甲基苯丙胺/成瘾机制/调控作用/差异性表达/研究进展Key words
forensic toxicology/microRNAs/methamphetamine/mechanism of addiction/regulatory role/differently expressed/research progress分类
医药卫生引用本文复制引用
何永旺,李娟,周一卿,赵祥月,杨根梦,张柠,曾晓锋,李桢..miRNAs在甲基苯丙胺成瘾中的作用研究进展[J].中国药理学通报,2017,33(8):1056-1060,5.基金项目
国家自然科学基金地区基金项目(No 81560303,81660310) （No 81560303,81660310）
云南省科技厅-昆明医科大学应用基础研究联合专项(No 2016 FB129) （No 2016 FB129）
云南省重大传染病疫苗研发重点实验室开放研究项目基金(No KF 2015-01) （No KF 2015-01）
昆明医科大学毒品滥用·法医病理学科技创新团队(No CXTD201604) （No CXTD201604）
