中国药业2017，Vol.26Issue(13)：21-23,3.DOI:10.3969/j.issn.1006-4931.2017.13.006
运脾化浊颗粒降脂减肥作用实验研究
Effect of Yunpihuazhuo Granule on Lipid-Lowering and Weight-Reducing
张小丽 1陈瑞明 1姜姗姗 1柴焱 1张涛2
作者信息
- 1. 陕西省中医药研究院中药研究所,陕西西安 710003
- 2. 清华德人西安幸福制药有限公司,陕西西安 710043
- 折叠
摘要
Abstract
Objective To observe the effect of Yunpihuazhuo Granule on lipid-lowering and weight-reducing. Mothods The high-fat fodder was used to feed and simultaneously administrate mice for 6 weeks, and the mice were weighed every 3 d, 12 h was fasted at the end of the last administration, the blood was collected from venous plexus of the fundus, then the mice were killed, the various indexes of blood lipid, fat weight around organ, viscera index and the weight loss index ( Lee′s index ) of the mice were measured. Results Obesity model could be obtained by feeding with this formula for 6 weeks. Male mice were more sensitive than female mice when duplicate. Yunpihuazhuo Granule can reduce the weight of fat around organ and viscera index of mice. The weight of mice was significantly reduced after 1-2 weeks of administration for large dose ( 16. 7 g/kg ) , medium dose ( 8. 3 g/kg ) and metformin hydrochloridepositive control group. For three doses of this product and the positive control, after different period of administration, the weight of mice was observed significantly reduced separately. TC, LDL-C, LDL-C/TC and atherogenic index of mice were significantly reduced. HDL-C/TC was significantly increased. The decrease of Lee′s index of male mice treated with large dose of Yunpihuazhuo Granule was extremely significant. Conclusion Yunpihuazhuo Granule has certain effect on anti-obesity action, it can significantly reduce various index and regulate the lipid metabolism.关键词
运脾化浊颗粒/小鼠/降脂减肥/调节脂代谢Key words
Yunpihuazhuo Granule/mice/lipid-lowering and weight-reducing/regulation of lipid metabolism分类
医药卫生引用本文复制引用
张小丽,陈瑞明,姜姗姗,柴焱,张涛..运脾化浊颗粒降脂减肥作用实验研究[J].中国药业,2017,26(13):21-23,3.
