中国药业2017，Vol.26Issue(14)：14-16,3.DOI:10.3969/j.issn.1006-4931.2017.14.005
顶空毛细管气相色谱法测定克林霉素磷酸酯中甲酸残留量
Content Determination of Formic Acid in Clindamycin Phosphate by Headspace Capillary GC
李超1
作者信息
- 1. 重庆市食品药品检验检测研究院,重庆 401121
- 折叠
摘要
Abstract
Objective To establish an headspace capillary GC method for the content determination of formic acid in clindamycin phos-phate. Methods Agilent DB-FFAP capillary column(30 m × 0. 32 mm,0. 5 μm)and FID were adopted. The inlet temperature was 200 ℃and the FID detector temperature was 250 ℃. The oven temperature was initially held at 40 ℃ for 7 min and was then programmed to 150 ℃ at 30 ℃ /min and held for 3 min. The head-space sampling was used at heated temperature 65 ℃ for 30 min. Results The concentration of formic acid was linear in the range of 0. 003743-0. 9980 g/L,r=0. 9992( n=8). The average recovery rate was 99. 30%,RSD=0. 64%( n=12). Conclusion The method is simple,sensitive,reproducible and accurate. It is suitable for the content determination of formic acid residue in clindamycin phosphate.关键词
克林霉素磷酸酯/甲酸/顶空进样法/毛细管气相色谱法/含量测定Key words
clindamycin phosphate/formic acid/head-space injecting method/capillary gas chromatography/content determination分类
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李超..顶空毛细管气相色谱法测定克林霉素磷酸酯中甲酸残留量[J].中国药业,2017,26(14):14-16,3.
