中国真菌学杂志2017，Vol.12Issue(3)：148-151,155,5.
白念珠菌氟康唑耐药株与敏感株SRB1、CDR1、ERG11表达比较分析
Analysis of expression of SRB1、 CDR1、 ERG11 in fluconazole sensitive and resistant Candida albicans strains
摘要
Abstract
Objective To investigate the differences in the expression of Candida albicans SRB1 in Candida albicans fluconazol resistant strain and sensitive strain,and to explore the relationship between SRB1 and drug resistance in Candida albicans.Methods Two Candida albicans strains were from a same parent.We used real-time RT-PCR to observe the expression of the target genes of SRB1,CDR1,ERG11 in Candida albicans fluconazole resistant strain CA-16 and sensitive strain CA-3.Result Compared with CA-3,the expression of the mRNA of SRB1 and drug resistance gene CDR1,ERG11 in CA-16 increased.There was significant difference in the expression levels of SRR1 、CDR1 and ERG11 (P ＜0.05).Conclusion The increased expression of SRB1 and the Candida albicans resistance to flueonazole was closely related,and SRB1 might be a new candidate genes associated with drug resistance.关键词
白念珠菌/耐药/基因/PCR/SRB1Key words
Candida albicans/drug resistance/gene/PCR/SRB1分类
医药卫生引用本文复制引用
高来强,王海英,王学红,李爱兰,马强,张宏..白念珠菌氟康唑耐药株与敏感株SRB1、CDR1、ERG11表达比较分析[J].中国真菌学杂志,2017,12(3):148-151,155,5.基金项目
山东省自然科学基金项目(ZR2015PH061) （ZR2015PH061）
