中国肿瘤生物治疗杂志2017，Vol.24Issue(6)：575-580,6.DOI:10.3872/j.issn.1007-385X.2017.06.001
实体肿瘤免疫治疗的关键问题与对策
Key problems and countermeasures of the immunotherapy for solid tumors
摘要
Abstract
In recent years,great breakthrough progresses have been achieved in cancer immunotherapy,cyto-imunotherapy with CAR-T as a representative has achieved encouraging clinical efficacy in the treatment of hematologic tumors,immune checkpoint inhibitor,CTLA-4 and PD-1/PD-L1 monoclonal antibodies,have been approved for clinical use in one after another.However,most of the patients with solid tumors did not get benefit from the immunotherapy.This paper summarized key problems that were difficult to resolve in the immunotherapy of solid tumors from aspects of screening individual noval antigen epitopes,maintaining viability of the immune cells,chemotaxis and invasion of the immunocytes,clinical treatment model,evaluation criterion and so on.And their coping strategies were described from the angle of clinical application.关键词
实体瘤/免疫治疗/新抗原/免疫卡控点/嵌合抗原受体T细胞/肿瘤微环境Key words
solid tumor/immunotherapy/neoantigen/immune checkpoints/chimeric antigen receptor T cell (CAR-T)/tumor microenvironment分类
医药卫生引用本文复制引用
刘宝瑞..实体肿瘤免疫治疗的关键问题与对策[J].中国肿瘤生物治疗杂志,2017,24(6):575-580,6.基金项目
国家自然科学基金资助项目(No.81672367).Project supported by National Natural Science Foundation of China (No.81672367) （No.81672367）
