中国肿瘤生物治疗杂志2017，Vol.24Issue(6)：660-664,5.DOI:10.3872/j.issn.1007-385X.2017.06.015
胃癌术后化疗联合自体肿瘤细胞抗原致敏DC-CIK细胞治疗的疗效
Efficacy of chemotherapy combined with autologous tumor antigen load dendritic cells-cytokine induced killer cell therapy in the treatment of gastric cancer patients after surgery
摘要
Abstract
Objective:To explore the clinical efficacy and safety of chemotherapy combined with autologous tumor antigen load dendritic cells-cytokin-induced killer (Ag-DC-CIK) cell therapy in the treatment of gastric cancer patients after D2 surgery.Methods:The present study enrolled 60 patients with gastric cancer in progressive stage (stage]Ⅱ,stage Ⅲ) who underwent D2 surgery in the department of gastrointestinal surgery,Jingzhou Central Hospital during January,2013 to March,2014.The patients were randomly divided into chemotherapy group (FOLFOX regimen for 6 cycles) and combined treatment group (FOLFOX chemotherapy for 6 cycles + Ag-DC-CIK cell therapy).The patients were followed up for two years.The two-year overall survival (OS) and progression free survival (PFS),the levels of T cell subsets in the peripheral blood (CD3 +,CD4 +,CD8 +,CD3 + CD56 +),quality of life and adverse reactions were evaluated in the two groups.Results:Compared to the chemotherapy group,the two-year OS and PFS were significantly higher in combined treatment group (both P ＜ 0.05).There was no significant difference in level of T cell subsets in peripheral blood of patients between pre-treatment and post-treatment in combined treatment group (P ＞ 0.05);however,the level of T cell subsets in the peripheral blood of patients of chemotherapy group decreased significantly (P ＜ 0.05),and it was significant lower than that of combined treatment group (P ＜ 0.05).Compared to the chemotherapy group,the combined treatment group had higher quality of life ([7.25 ± 1.56] vs [5.54 ± 1.27],P ＜ 0.05) and lower adverse reactions (10.0％ vs 20.0％,P ＜ 0.05).Conclusion:Ag-DC-CIK cell therapy in combination with chemotherapy,compared with chemotherapy alone,can obviously increase the two-year OS and PFS,protect the immune function of patients,reduce the adverse reactions and improve quality of life for gastric cancer patients.关键词
胃癌/化疗/自体肿瘤细胞抗原/树突状细胞/细胞因子诱导的杀伤细胞/自体肿瘤细胞抗原致敏树突状细胞-细胞因子诱导的杀伤细胞Key words
gastric cancer/chemotherapy/autologous tumor antigen/dendritic cells/cytokine-induced kill cells/autologous tumor antigen load dendritic cells-cytokin-induced killer (Ag-DC-CIK) cell分类
医药卫生引用本文复制引用
张子龙,曾放,庞典付,张克难..胃癌术后化疗联合自体肿瘤细胞抗原致敏DC-CIK细胞治疗的疗效[J].中国肿瘤生物治疗杂志,2017,24(6):660-664,5.基金项目
荆州市科技发展计划资助项目(No.2014048).Project supported by the Science and Technology Support Project of Jingzhou City (No.2014048) （No.2014048）
