中华骨质疏松和骨矿盐疾病杂志2017，Vol.10Issue(3)：290-296,7.DOI:10.3969/j.issn.1674-2591.2017.03.015
骨质疏松症的表观遗传学调控
Epigenetic regulation of osteoporosis
张蓓蓓 1商玮 1蔡辉1
作者信息
- 1. 210002南京,南京军区南京总医院中西医结合科
- 折叠
摘要
Abstract
Epigenetic modification indicates the inheritable alteration of gene expression without changing DNA sequence,including DNA methylation,histone modifications,non-coding RNAs and chromatin modifications etc.Osteoporosis is the most common bone disease characterized by decreased bone strength and bone micro-architectural deterioration,an increased risk of fractures.Nowadays it is well accepted that epigenetic regulation is deeply involved in the occurrence and development of osteoporosis.Epigenetic modification regulates the expression of important genes in the differentiation of osteoblasts and osteoclasts and osteoblast-to-osteocyte transition,even the crosstalk between osteoblasts and osteoclasts.Epigenetically active drugs have already shown potential for the treatment of osteoporosis.关键词
表观遗传学/骨质疏松症/骨稳态/DNA甲基化/组蛋白修饰Key words
epigenetic/osteoporosis/bone homeostasis/DNA methylation/histone modification分类
医药卫生引用本文复制引用
张蓓蓓,商玮,蔡辉..骨质疏松症的表观遗传学调控[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(3):290-296,7.
