中成药2017，Vol.39Issue(7)：1347-1350,4.DOI:10.3969/j.issn.1001-1528.2017.07.004
七宝美髯口服液对小鼠脑组织SOD活力及羰基化蛋白含量的影响
Effects of Qibao Meiran Oral Liquid on SOD activity and carbonyl protein content in brain tissue of mice
摘要
Abstract
AIM To observe the effects of Qibao Meiran Oral Liquid (Polygoni multiflori Radix Praeparata,Angelicae sinensis Radix,Psoraleae Fructus,etc.) on learning and memory function,hippocampus tissue pathological morphology,SOD activity and carbonyl protein content in SAMP8 mice.METHODS Twenty-seven SAMP8 mice were randomly and equally divided into model control group,donepezil hydrochloride group and Qibao Meiran Oral Liquid group.Another nine SAMR1 mice were selected as normal control group.Mice were given successive intragastric administration for 60 days.On the 56th day,the passive avoidance test was adopted,and the learning and memory capacities were determined after 5 d;The pathological morphology was observed by HE staining;ELISA assay was used to detect the activity of SOD and the content of carbonyl protein in brain tissue.RESULTS Compared with the model control group,the escape latency of mice in the Qibao Meiran Oral Liquid group was significantly prolonged,and the number of errors decreased significantly (P ＜0.01);the pathological morphology of hippocampus tissue was significantly improved;SOD activity increased significantly,and carbonyl protein content decreased significantly (P ＜ 0.01).CONCLUSION Qibao Meiran Oral Liquid can not only improve the learning and memory function of SAMP8 mice,but also reduce the degree of hippocampus tissue degenerative disease.关键词
七宝美髯口服液/退行性病变/SOD/羰基化蛋白/SAMP8小鼠Key words
Qibao Meiran Oral Liquid/degenerative disease/SOD/carbonyl protein/SAMP8 mice分类
医药卫生引用本文复制引用
孟诗,魏江平,郑航,吴倩,付昆,张占军,徐世军..七宝美髯口服液对小鼠脑组织SOD活力及羰基化蛋白含量的影响[J].中成药,2017,39(7):1347-1350,4.基金项目
国家自然科学基金重点项目(81430100) （81430100）
四川省学术和技术带头人培养资金资助项目(2015058) （2015058）
中药药理四川省青年科技创新研究团队项目(2014TD0007) （2014TD0007）
