中成药2017，Vol.39Issue(7)：1351-1355,5.DOI:10.3969/j.issn.1001-1528.2017.07.005
藏药佐太中汞在小鼠体内的蓄积
Mercury accumulation of Tibetan medicine Zuotai in mice
摘要
Abstract
AIM To explore the mercury accumulation in KM mice after being given Zuotai at different doses and time.METHODS KM mice were randomly divided into blank group,Zuotai low-,middle-and high-dose (6.07,60.70 and 606.97 mg/kg,42 d;606.97 mg/kg,14 d) groups.The mercury contents in brain (olfactory bulb,cortex,hippocampus,hypothalamus,brain stem,cerebellum),heart,lung,kidney,liver,spleen,serum,muscle of mice were measured after administration.RESULTS Compared with the blank group,Zuotai at low-dose significantly increased the mercury contents in hippocampus,cerebellum,lung,kidney,liver and serum of mice after 42-day treatment;Zuotai at middle-dose markedly increased the mercury contents in olfactory bulb,cortex,hippocampus,brain stem,cerebellum,heart,lung,kidney,liver,spleen and serum of mice after 42-day treatment;the mice treated with high-dose of Zuotai for 42,14 days significantly increased the mercury contents in olfactory bulb,cortex,hippocampus,hypothalamus,brain stem,cerebellum,heart,lung,kidney,liver,spleen,muscle and serum.CONCLUSION Mercury can be accumulated in different tissues of mice after intragastric administration of Zuotai in a dose-and time-dependent manner,which suggests that Zuotai and its compound preparations should not be used in high-dose and long-term.关键词
佐太/汞/蓄积/小鼠Key words
Zuotai/mercury/accumulation/mice分类
医药卫生引用本文复制引用
赵静,杜玉枝,魏立新,牛翠英,张吉余..藏药佐太中汞在小鼠体内的蓄积[J].中成药,2017,39(7):1351-1355,5.基金项目
国家自然科学基金面上项目(81374063) （81374063）
青海省重点实验室发展专项(2014-Z-Y02) （2014-Z-Y02）
中国科学院“西部之光”重点项目(Y529021211) （Y529021211）
