中成药2017，Vol.39Issue(7)：1365-1368,4.DOI:10.3969/j.issn.1001-1528.2017.07.008
血必净注射液对重度急性有机磷农药中毒患者血清CRP、TNF-α及IL-6水平的影响
Effects of Xuebijing Injection on serum CRP, TNF-α and IL-6 levels in patients with severe acute organophosphorus pesticide poisoning
田应海 1陈秋霞 1邓小莹 1陈树波 1吴方明 1皮斌 1陈玉娟1
作者信息
- 1. 广州医科大学附属第五医院急诊科,广东广州510700
- 折叠
摘要
Abstract
AIM To explore the effects of Xuebijing Injection (Carthami Flos,Salviae miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra,etc.) on serum CRP,TNF-α and IL-6 levels in patients with severe acute organophosphorus pesticide poisoning (AOPP).METHODS Seventy-two cases of patients with AOPP treated from Jan 2014 to Mar 2016 in the emergency department of our hospital were randomly divided into two groups,the control group treated with atropine,pralidoxime chloride and conventional treatment,and the observation group combined with Xuebijing Injection.The dynamic changes of serum CRP,TNF-α and IL-6 levels,and clinical curative effects were compared between the two groups.RESULTS The serum CRP,TNF-α and IL-6 levels in the two groups were decreased in turn before the treatment,at the 3rd,7th days after the treatment,and the serum CRP,TNF-α and IL-6 levels in the observation group were significantly lower than those in the control group;the dosage of atropine,time of cholinesterase activity recovered 60％ and hospital stay in the observation group were significantly less than those in the control group;the rebound rate of the observation group was lower than that of the control group.The acute respiratory distress syndrome (ARDS) rate in the observation group was significantly lower than that in the control group.All the differences had statistical significances (P ＜ 0.05).CONCLUSION Xuebijing Injection can effectively inhibit the inflammatory response,reduce the incidence of complications,shorten the course,and improve the clinical efficacy in the treatment of patients with AOPP.关键词
血必净注射液/急性有机磷农药中毒/全身炎症反应综合征/多脏器功能障碍综合征Key words
Xuebijing Injection/acute organophosphate pesticide poisoning/systemic inflammatory response syndrome/multiple organ dysfunction syndrome分类
医药卫生引用本文复制引用
田应海,陈秋霞,邓小莹,陈树波,吴方明,皮斌,陈玉娟..血必净注射液对重度急性有机磷农药中毒患者血清CRP、TNF-α及IL-6水平的影响[J].中成药,2017,39(7):1365-1368,4.
