浙江医学2017，Vol.39Issue(10)：782-785,4.DOI:10.12056/j.issn.1006-2785.2017.39.10.2016-1532
输卵管积水和阻塞患者的试管婴儿结局及与血清抗苗勒氏管激素的关系
Association between serum anti-Mullerian hormone levels and IVF-ET outcomes in infertile women with salpingemphraxis
摘要
Abstract
Objective To investigate the association between serum anti-Mullerian hormone (AMH) levels and in vitro fertilization-embryo transfer (IVF-ET) outcomes in infertile women with salpingemphraxis and hydrosalpinx.Methods One hundred and sixty salpingemphraxis infertile females undergoing IVF-ET were enrolled in the study,including 106 women with simple salpingemphraxis (salpingemphraxis group) and 54 women with salpingemphraxis and hydrosalpinx(hydrosalpinx group).Serum AMH levels were measured by ELISA method and compared between two groups,and between those with different IVF-ET outcomes.Results Gn dosage was significantly higher in hydrosalpinx group than that in salpingemphraxis group (P＜ 0.05).The D3 quality embryo rate and pregnancy rate in hydrosalpinx group was significantly lower than those in salpingemphraxis group (P＜0.05).There was no significant difference in serum AMH levels between two groups (P ＞0.05).Serum AMH level was negatively correlated with age and Gn dose in two groups(r =-0.083,P=0.028 and r =-0.382,P=0.005,r =-0.444,P=0.020 and r=-0.573,P=0.001),and positively correlated with the number of retrieved oocytes in two groups (r=0.385,P=0.047 and r =0.295,P=0.032).There was no association of serum AMH levels with the D3 quality embryo rate,blastocyst rate and clinical pregnancy rate in two groups (all P ＞0.05).Conclusion Hydrosalpinx patients need more Gn but with reduced clinical pregnancy rate in IVF-ET.Hydrosalpinx has no significant affect on ovarian function and serum AMH level.AMH level may predict Gn dosage and the number of retrieved oocytes in patients with hydrosalpinx during controlled ovarian stimulation,and can't refer to the quality of embryos and IVF-ET's clinical outcomes.关键词
输卵管性不孕/输卵管阻塞/输卵管积水/抗苗勒氏管激素/体外受精-胚胎移植Key words
Tubal infertility/Salpingemphraxis/Hydrosalpinx/Anti-Mullerian hormone/In vitro fertilization-embryo transfer引用本文复制引用
应映芬,黄朝霞,陈益鲁,王琳,吕杰强,赵军招..输卵管积水和阻塞患者的试管婴儿结局及与血清抗苗勒氏管激素的关系[J].浙江医学,2017,39(10):782-785,4.基金项目
温州市科技局科技计划项目(Y20150213) （Y20150213）
