浙江医学2017，Vol.39Issue(10)：816-818,3.DOI:10.12056/j.issn.1006-2785.2017.39.10.2016-1353
2型糖尿病患者血浆同型半胱氨酸与血糖波动的相关性研究
The relationships between homocysteine and glycemic variability in type 2 diabetes mellitus
摘要
Abstract
Objective To explore the relationships between homocysteine and glycemic variability in patients with type 2 diabetes mellitus.Methods A total of 120 patients with type 2 diabetes mellitus was enroll in the research.All of them were divided separately by the level of homocystiene (HHcy and NHcy),then blood glucose and insulin function will be tested and calculated.Evaluate the relationships by obtaining the laboratory index,HOMA factors and glycemic variability parameters after continuously monitoring glucose.Results Factors such as MODD,HOMA-IR,Scr,mAlb and UAER in HHcy are higher than ones in NHcy (all P＜0.05),and other factors like MBG,HbA1c,MAGE,HOMA-B,HOMA-S,BUN,GFR seem no significant differences in two groups (all P ＞0.05).Pearson analysis shows levels of Hcy have positive correlation with MAGE (r=0.548,P＜ 0.01),while they're negatively related to GFR(r=-0.577,P＜0.01).Conclusion This study demonstrates homocysteine may reflect renal function,insulin sensitivity and resistance in type 2 diabetes patients.Also,the results suggest that the Hcy may be of limited value for assessing glucose variability in the patients with type 2 daibetes mellitus,it also can be chosen as a convenient indicator for glucose variability.关键词
2型糖尿病/同型半胱氨酸/动态血糖监测Key words
Type 2 diabetes mellitus/Homocystiene/Continuous glucose monitoring system引用本文复制引用
褚建平,钮雁文,吴凌云,郑筱玮,徐淼,王兴珍,李佳霖,林仿,卢杰,毛洲宏,励丽..2型糖尿病患者血浆同型半胱氨酸与血糖波动的相关性研究[J].浙江医学,2017,39(10):816-818,3.基金项目
宁波市科学技术局社会发展攻关项目(201401C5010047) （201401C5010047）
