中药材2017，Vol.40Issue(2)：342-346,5.DOI:10.13863/j.issn1001-4454.2017.02.020
红树林内生真菌Aspergillus sp.085035次级代谢产物研究
Secondary Metabolites of Mangrove Endophytic Fungus Aspergillus sp.085035
摘要
Abstract
Objective:To study the secondary metabolites of Aspergillus sp.085035 from South China Sea.Methods:The metabolites of Aspergillus sp.085035 were isolated and purified by silica gel column chromatography and semipreparative HPLC,and their structures were elucidated by MS and NMR spectra,and then confirmed by a single-crystal X-ray crystallographic analysis.The cytotoxicity of the compounds was tested by MTT assay.Results:Nine compounds were isolated from the mangrove endophytic fungus Aspergillus sp.085035,and their structures were identified as 13R-fumigaclavine C (1),8'-O-methylasterric acid (2),1,2-seco-trypacidin (3),rhizoctonic acid (4),chaetominine (5),helvolic acid (6),trypacidin (7),emodin-8-methylether (8) and fumitremorgin C (9).Conclusion:Compound 1 is a new natural product,compounds 1,8 are isolated from Aspergillas sp.genus for the first time,all the compounds are isolated from this furgus for the first time.Compound 7 exhibits cytotoxicity against MDA-MB-435 cells.关键词
红树林/内生真菌/次级代谢产物/Aspergillus sp.085035/13R-fumigaclavine CKey words
Mangrove/Endophytic fungus/Secondary metabolites/Aspergillus sp.085035/13R-fumigaclavine C分类
医药卫生引用本文复制引用
张柳红,王嘉健,洪葵,林永成,李静,刘岚..红树林内生真菌Aspergillus sp.085035次级代谢产物研究[J].中药材,2017,40(2):342-346,5.基金项目
国家自然科学基金(21272268) （21272268）
海洋生物天然产物化合物库基金(4109041) （4109041）
