中国现代中药2017，Vol.19Issue(6)：794-797,4.DOI:10.13313/j.issn.1673-4890.2017.6.012
清热养心颗粒对大鼠灌服环孢素药动学影响
Effect of Qingreyangxin Granule on Pharmacokinetics of Intragastrically Administered Cyclosporine A in Rats
摘要
Abstract
Objective:To investigate the pharmacokinetic effect of Qingreyangxin granule (QG) on cyclosporine A (CsA) in rats.Methods:Concentration of cyclosporine A in rat whole blood was detected by UHPLC-MS/MS after rats were oral administration of QG or QG combined with CsA.Pharmacokinetic parameters were calculated by DAS 3.0 pharmacokinetic software.Results:In vivo pharmacokinetic models of CsA.were one-compartment open models in both of the QG group and the QG combined with CsA group.After compatibility,CsA showed a significant longer in t1/2,with significant increase in AUC.Conclusion:QG can reduce metabolic process of CsA in vivo.关键词
清热养心颗粒/环孢素/大鼠/药代动力学/超高效液相串联质谱Key words
Qingreyangxin granule/cyclosporine A/rat/pharmacokinetics/UHPLC-MS/MS引用本文复制引用
吴磊,戴国梁,王琼,陆超..清热养心颗粒对大鼠灌服环孢素药动学影响[J].中国现代中药,2017,19(6):794-797,4.基金项目
江苏省中医药管理局项目(JD201512) （JD201512）
江苏省药学会-奥赛康医院药学基金(A201607) （A201607）
