重庆医学2017，Vol.46Issue(21)：2884-2888,5.DOI:10.3969/j.issn.1671-8348.2017.21.002
磁共振DTI定量评价脉络宁注射液对非压迫性腰神经根炎疗效的实验研究
An experimental study of magnetic resonance DTI quantitative evaluation on effect of Mailuoning Injection for non-compressive lumbar radiculitis
摘要
Abstract
Objective To investigate use of magnetic resonance diffusion tensor imaging (MR-DTI) for quantitatively evaluating the efficacy of Mailuoning Injection on non-compressive lumbar radiculitis.Methods Nine Bama mini pigs were selected and divided into group A,B and C,3 cases in each group.The non-compressive lumbar radiculitis model was established under CT-guiding.The corresponding therapeutic drugs (group A:10 mL Mailuoning;group B:10 mL normal saline;group C:10 mL diminishing inflammation fluid) were given by epidural injection on 14 d after constructing model.MR-DTI was performed before model construction,14 d after model construction and before treatment.One experimental pig in each group was taken on 3,7,14 d after treatment,performed MR-DTI and killed for taking the nerve root sample to conduct the immunohistochemical detection.The fractional anisotropy (FA) values of nerve root in MR-DTI imaging were measured.The FA values and immunohistochemical detection results were statistically analyzed.Results MR-DTI:the FA values after model construction in each group was decreased (P<0.05);the FA values on 14 d after treatment in the group A was increased,which showed statistically significant difference compared with before treatment (P<0.05);the FA values after 3,7 d treatment in the group A had no obvious increase,the difference between the group A and B was not statistically significant (P>0.05),but the FA values increase in the group C was earlier and more rapid than other two groups (P<0.05);the FA values after 14 d treatment in the group A was risen again,the FA values of bilateral nerve roots had no statistical difference between the group A with the group B and C (P>0.05),while the FA values had statistical difference between the group B and C (P<0.05).The immunohistochemical results:TNF-α integral absorbency value(IA value) on 7 d after treatment in the group A began to decline;the TNF-α IA value on 14 d after treatment in the group A and C was significantly decreased compared to group B,the difference was statistically significant (P<0.05).Conclusion Mailuoning Injection has a certain effect on non-compressive lumbar radiculitis,which can be evaluated by using DTI.关键词
磁共振成像/扩散张量成像/神经根炎/外科手术,微创性/脉络宁注射液Key words
magnetic resonance imaging/diffusion tensor imaging/radiculitis/surgical procedures,minimally invasive/Mailuoning Injection分类
医药卫生引用本文复制引用
彭涛,牛翔科,肖建明,王宗勇,植彪,杨朝炳,陈云涛,杨玺,韩立新..磁共振DTI定量评价脉络宁注射液对非压迫性腰神经根炎疗效的实验研究[J].重庆医学,2017,46(21):2884-2888,5.基金项目
四川省医学科研青年创新课题计划项目(Q14004). （Q14004）
