分析测试学报2017，Vol.36Issue(1)：61-66,6.DOI:10.3969/j.issn.1004-4957.2017.01.010
磁性多壁碳纳米管固相萃取/高效液相色谱-串联质谱法测定蜂蜜中多组分兽药残留
Determination of Veterinary Drugs Residues in Honey by High Performance Liquid Chromatography-Tandem Mass Spectrometry with Magnetic Multi-walled Carbon Nanotubes
摘要
Abstract
A method using magnetic multi-walled carbon nanotubes (mMWCNTs) as the absorbent followed by ultra-performance liquid chromatography-tandem mass spectrometry was established for the determination of 44 veterinary drugs residues in honey.Analytes were extracted with Na2EDTA-Mcllvaine buffer solution (pH 4.0) before self-made mMWCNTs were added to absorb veterinary drugs.After extraction with mMWCNTs and followed by elution with 10％ ammonia-methanol,target analytes were analyzed using multiple reaction monitoring (MRM) mode.The correlation coefficients of linear calibration curves were over 0.99 in the concentration range of 1-40 ng/mL.The recoveries of 44 analytes at three spiked concentrations ranged from 78.0％ to 105.1％,with relative standard deviations(RSDs) of 1.2％-8.9％.The limits of detection(LODs,S/N≥3) were 0.2-2.0 μg/kg.With the advantages of simplicity,sensitivity and good precision,this method provides a new way for the determination of multi-veterinary drug residues in honey.关键词
磁性多壁碳纳米管/磺胺/硝基咪唑/喹诺酮/蜂蜜Key words
magnetic multi-walled carbon nanotubes/sulfonamide/nitroimidazole/quinolone/honey分类
化学化工引用本文复制引用
徐潇颖,罗金文,陈万勤,赵超群,刘柱..磁性多壁碳纳米管固相萃取/高效液相色谱-串联质谱法测定蜂蜜中多组分兽药残留[J].分析测试学报,2017,36(1):61-66,6.基金项目
浙江省科技计划项目(2015C37054) （2015C37054）
浙江省科技厅重大项目(2014C02001) （2014C02001）
