广东医学2017，Vol.38Issue(11)：1699-1702,4.
血管紧张素Ⅱ和C反应蛋白对发热伴血小板减少综合征的早期诊断及预后评估价值研究
The value of angiotensin Ⅱ and C reactive protein in early diagnosis and prognosis evaluation of fever with thrombocytopenia syndrome
摘要
Abstract
Objective To analyze the levels of angiotensin Ⅱ (Ang Ⅱ) and C reactive protein (CRP) in patients with fever of thrombocytopenia syndrome (SFTS) and their correlations with clinical parameters,and to study the clinical values of Ang Ⅱ and CRP in early diagnosis and prognosis of SFTS.Methods A total of 72 cases of SFTS were collected and divided into normal group and critical group.The blood samples of all cases in the acute phase and recovery phase were collected for assessment of Ang lⅡ,CRP,serum viral load,blood routine,and biochemical indexes.The correlations of Ang Ⅱ and CRP with serum viral load,leukocyte (WBC),platelet (PLT) and serum enzymology were analyzed.Thew ROC curve was applied to evaluate the predictive value of Ang Ⅱ and CRP on severity and outcome of SFTS.Another 31 healthy subjects were selected as control.Results Ang Ⅱ and CRP levels were significantly increased in acute phase,negatively correlated with WBC and PLT counts,and positively correlated with serum viral load,ALT,AST,LDH,CK,and CK-MB.The severer the illness was,the higher the Ang Ⅱ and CRP were.The levels of Ang Ⅱ and CRP in recovery period were significantly reduced.The areas under ROC curve (AUCs) of Ang Ⅱ and CRP were 0.880 and 0.703,respectively.Conclusion Ang Ⅱ and CRP can be used as important reference indexes for early diagnosis,prognosis and prognostic evaluation of SFTS.Compared with CPR,the prediction value of Ang Ⅱ is better.关键词
发热/血小板减少综合征/血管紧张素Ⅱ/C反应蛋白Key words
fever/thrombocytopenia syndrome/angiotensin Ⅱ/C reactive protein引用本文复制引用
倪秀莹,孙朝霞,程素洁,李少华,杨谦,吴翠萍..血管紧张素Ⅱ和C反应蛋白对发热伴血小板减少综合征的早期诊断及预后评估价值研究[J].广东医学,2017,38(11):1699-1702,4.基金项目
山东省潍坊市卫生局科研项目计划(编号:2013105) （编号:2013105）
