张渊源 1赵谦 2李晓虹 3史瑞明 1周铭 1高文娟1
作者信息
- 1. 西安交通大学第一附属医院儿科,陕西西安710061
- 2. 西安交通大学第一附属医院耳鼻喉科,陕西西安710061
- 3. 西安医学院,陕西西安710021
- 折叠
摘要
Abstract
Objective To evaluate the clinical significance of tidal breathing lung function test in children under 5 years old with wheezing diseases.Methods A total of 159 children under 5 years old (including 5 years) with wheezing diseases were enrolled in observation group,and they were divided into bronchopneumonia group (94 cases),asthmatic bronchitis group (12 cases),and asthma group (53 cases).Another 64 children without respiratory diseases were enrolled in control group.All the children underwent tidal breathing lung function test.Lung function and improvement rate of children with wheezing diseases were observed before and after bronchodilation test.Results The observed groups showed obstructive ventilatory disorder (83.02％) according to tidal breathing flow volume curve (TBFV) loop.Before medication,the differences among groups were statistically significant in tidal volume per kilogram (Vt),respiratory rate (RR),inspiratory time (Ti),expiratory time (Te),ratio of time to peak tidal expiratory flow to total expiratory time (TPTEF/TE),and ratio of volume to peak expiratory flow to total expiratory volume (VPEF/VE) (F value was 13.21,4.91,3.08,2.74,36.50 and 40.00,respectively,all P ＜ 0.05).In bronchopneumonia group TPTEF/TE and VPTEF/VE after bronchial dilation test were significantly different from those before test (t value was 2.86 and 3.14,respectively,both P ＜ 0.05).In asthma group differences in TPTEF/TE and VPTEF/VE before and after bronchial dilation test were not significant (t value was 1.36 and 1.18,respectively,both P ＞0.05).There were no significant differences in the improvement rate of TPTEF / TE and VPTEF / VE before and after bronchodilator test among different groups (x2 value was 0.02 and 0.91,respectively,both P ＞0.05).Taking an improvement rate of higher than 15％ either for TPTEF/TE or for VPTEF/VE as an indicator of positive bronchial dilation test,the bronchial dilation test had a sensitivity of 20.75％ and a specificity of 73.58％ in diagnosing asthma in children under 5 years old.Conclusion Obstructive ventilatory disorder is the main impairment of tidal breathing lung function in children under 5 years old with wheezing diseases.Tidal breathing bronchial dilation test can reflect a reversal of airway obstruction to a certain extent.But the sensitivity of bronchial dilation test for the diagnosis of asthma is not high in children under 5 years old with wheezing diseases.关键词
潮气呼吸肺功能/哮喘/喘息性支气管炎/支气管肺炎/儿童Key words
tidal breathing lung function/asthma/asthmatic bronchitis/bronchopneumonia/children分类
医药卫生
