中国妇幼健康研究2017，Vol.28Issue(6)：659-661,3.DOI:10.3969/j.issn.1673-5293.2017.06.014
小儿支气管哮喘血T、B淋巴细胞异常表达的临床意义
Clinical significance of abnormal expressions of T and B lymphocytes in children with bronchial asthma
摘要
Abstract
Objective To investigate the clinical significance of abnormal expressions of T and B lymphocytes in children with bronchial asthma.Methods Altogether 198 children with bronchial asthma treated in Ya' an People' s Hospital from January to October in 2016 were selected as study objects (asthma group),and healthy children receiving physical examination at the same time were randomly selected as control group according to 1:1 matching.In asthma group there were 107 cases in acute stage and 91 cases in remission stage,and 198 children were in the control group.T lymphocyte (CD3,CD3 + CD4 +,CD3 + CD8 + and CD4 +/CD8 +) and B lymphocyte (CD19 + CD23 +) in peripheral blood of children in acute stage and in remission stage and of children in the control group were tested,and relative indexes were compared.Results Levels of CD3 + CD4 + and CD19 + CD23 + of cases in acute stage were significantly higher than those in remission stage (t value was 2.479 and 2.341,respectively,both P ＜ 0.05) and those in the control group (t value was 2.421 and 2.524,respectively,both P ＜ 0.05).Level of CD4 +/CD8 + of cases in acute stage was significantly higher than that of cases in remission stage and in the control group,and the differences had statistic significance (t value was 2.516 and 2.325,respectively,both P ＜ 0.05).Conclusion Expressions of T and B lymphocytes in peripheral blood of children with bronchial asthma are obviously highexpressed,which can be used as an index to evaluate the severity and therapeutic effect of bronchial asthma.关键词
支气管哮喘/B淋巴细胞/T淋巴细胞/儿童/治疗效果Key words
bronchial asthma/B lymphocytes/T lymphocytes/children/therapeutic effect分类
医药卫生引用本文复制引用
文勃,王成林,罗丽,冯杨..小儿支气管哮喘血T、B淋巴细胞异常表达的临床意义[J].中国妇幼健康研究,2017,28(6):659-661,3.
