摘要
Abstract
Objective To study the expressions of carbonic anhydrase IX (CAIX) and vascular endothelial growth factor (VEGF) in ovarian epithelial tumor and their relationship with tumorigenesis and progression of malignant ovarian epithelial tumor.Methods SP immunohistochemistry method was used to examine the expressions of CAIX and VEGF in 45 cases of benign ovarian epithelial tumor, 50 cases of borderline ovarian epithelial tumor and 61 cases of malignant ovarian epithelial tumor.Results The expressions of CAIX and VEGF in malignant ovarian epithelial tumor was 59.00% and 70.50%, respectively, which were significantly higher than those in benign ovarian epithelial tumor and borderline ovarian epithelial tumor with statistical significance (χ2 value was 18.14, 5.83, 21.97 and 7.95, respectively, all P<0.05).The expressions of CAIX and VEGF in malignant ovarian epithelial tumor were closely related with degree of tumor differentiation, invasion and metastasis (χ2 value was 13.16, 12.19, 8.50, 20.61, 26.39 and 11.24, respectively, all P<0.01), but they were not correlated with type of tumor and patient''s age (χ2 value was 0.20, 0.79, 0.01 and 0.01, respectively, all P>0.05).Conclusion The expressions of CAIX and VEGF in malignant ovarian epithelial tumor are closely related with staging of tumor and prognosis.Detecting CAIX and VEGF may provide some evidence for judging the metastasis and staging of malignant ovarian epithelial tumor and thus becomes an important index for predicting prognosis of malignant ovarian epithelial tumor.关键词
碳酸酐酶IX/血管内皮生长因子/卵巢上皮性肿瘤/免疫组化Key words
carbonic anhydrase IX (CAIX)/vascular endothelial growth factor (VEGF)/ovarian epithelial neoplasm/immunohistochemistry分类
医药卫生
