解放军医药杂志2017，Vol.29Issue(6)：19-21,32,4.DOI:10.3969/j.issn.2095-140X.2017.06.005
急性白血病患者血清IFN-γ、TGF-β、IL-6和IL-17水平及临床意义
Levels of Serum IFN-γ TGF-β, IL-6 and IL-17 of Patients with Acute Leukemia and Their Clinical Significances
摘要
Abstract
Objective To study levels of serum interferon gamma (IFN-γ),transforming growth factor-β (TGF-β),interleukin-6 (IL-6) and IL-17 expressions of patients with acute leukemia and their clinical significances.Methods A total of 96 patients with acute leukemia admitted during April 2014 and March 2016 were divided into acute lymphoblastic leukemia (ALL) group (n =35) and acute myeloid leukemia (AML) group (n =61) according to FAB classification criteria,and other 96 healthy people taking medical examination were selected as the control group.Levels of serum IFN-γ,TGF-β,IL-6 and IL-17 expressions were detected by enzyme linked immunosorbent assay (ELISA) before and after treatment in ALL and AML group and in control group.Results Compared with those in control group,serum IFN-γ levels were significantly lower before treatment (P ＜ 0.05),while serum TGF-β,IL-6 and IL-17 levels were significantly higher in ALL and AML groups (P ＜ 0.05).Serum IFN-γ and IL-6 levels in ALL group were significantly higher than those in AML group (P ＜ 0.05).In ALL and AML groups,after treatment,in complete remission patients,serum IFN-γlevels were significantly higher (P ＜ 0.05),while TGF-β,IL-6 and IL-17 levels were significantly lower than those in non-remission patients (P ＜ 0.05).In ALL and AML groups,IFN-γ level was negatively correlated with TGF-β,IL-6 and IL-17 levels (P ＜0.05),and TGF-β level was positively correlated with IL-6 and IL-17 levels (P ＜0.05),and IL-6 level was positively correlated with IL-17 level (P ＜ 0.05).Conclusion Serum IFN-γ,TGF-β,IL-6 and IL-17 are related to pathogenesy and development of acute leukemia,and therefore it can be used as important indicators in clinical diagnosis of acute leukemia and prognosis evaluation.关键词
白血病/干扰素-γ/转化生长因子-β/白介素-6/白介素-17Key words
Leukemia/Interferon-γ/Transforming growth factor-β/Interleukin-6/Interleukin-17分类
医药卫生引用本文复制引用
何光翠,邓锐,刘一岚,苏毅,范方毅..急性白血病患者血清IFN-γ、TGF-β、IL-6和IL-17水平及临床意义[J].解放军医药杂志,2017,29(6):19-21,32,4.基金项目
四川省卫生厅课题(120565) （120565）
