解放军医药杂志2017，Vol.29Issue(6)：78-81,4.DOI:10.3969/j.issn.2095-140X.2017.06.022
2型糖尿病肾病患者外周血IGF-1、TGF-β和VEGF水平及临床意义
Levels and Clinical Significances of IGF-1, TGF-β and VEGF in Patients with Type 2 Diabetic Nephropathy
摘要
Abstract
Objective To investigate levels and clinical significances of insulin-like growth factor-1 (IGF-1),transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) in patients with type 2 diabetic nephropathy.Methods A total of 100 patients with type 2 diabetic nephropathy admitted during October 2014 and May 2016 were divided into normal albuminuria group (n =34),microalbuminuria group (n =32) and high albuminuria group (n =34) according to urinary albumin excretion contents within 24 h,and other 32 healthy people were selected as control group.Peripheral blood and urine samples were collected,and IGF-1,TGF-β and VEGF levels and other clinical indexes were detected and analyzed.Results Creatinine,urea nitrogen and systolic blood pressure levels were increased with increasing urine protein level in patients with type 2 diabetic nephropathy (P ＜ 0.05).IGF-1 level in high albuminuria group was significantly higher than those in control,normal albuminuria and microalbuminuria groups (P ＜ 0.05).Levels of TGF-β and VEGF in normal albuminuria,microalbuminuria and high albuminuria groups were significantly higher than those in control group (P ＜ 0.01);TGF-β level in high albuminuria group was significantly higher than that in normal albuminuria and microalbuminuria groups (P ＜ 0.05);VEGF levels in high albuminuria and microalbuminuria groups were significantly higher than those in normal albuminuria group (P ＜ 0.05).Conclusion Detection for IGF-1,TGF-and VEGF levels can effectively evaluate degree of renal damage and guide the clinical treatment in time in patients with type 2 diabetic nephropathy.关键词
糖尿病肾病/胰岛素样生长因子-1/转化生长因子β/血管内皮生长因子Key words
Diabetic nephropathies/Insulin-like growth factor-1/Transforming growth factor β/Vascular endothelial growth factor分类
医药卫生引用本文复制引用
姚向飞,蔡东,权皎洁..2型糖尿病肾病患者外周血IGF-1、TGF-β和VEGF水平及临床意义[J].解放军医药杂志,2017,29(6):78-81,4.基金项目
陕西省自然科学基金项目(2002C218) （2002C218）
