中国实用神经疾病杂志2017，Vol.20Issue(13)：5-8,4.
间歇与连续性透析对终末期肾病合并脑出血患者血流动力学影响的对照研究
Controlled study of the effect of intermittent and continuous dialysis on hemodynamics in patients with end stage renal disease complicated with cerebral hemorrhage
摘要
Abstract
Objective To investigate the effects of different dialysis modes (intermittent and continuous) on the hemodynamics of patients with end-stage renal disease complicated with cerebral hemorrhage.Methods A total of 36 patients with end-stage renal disease complicated with cerebral hemorrhage were selected from January 2010 to December 2016,and were randomly divided into intermittent dialysis group and continuous dialysis group.The hemodynamics indexes,changes of intracranial pressure,changes of vasoactive peptides,oxidative and inflammatory factors were analyzed and compared between the two groups.Results There were no significant differences in the degree of brain damage and clinical manifestation between the two groups.There was no significant difference in mean blood pressure between the two dialysis models.The increase of cardiac output during intermittent dialysis and continuous dialysis was 5.2%±1.8%,4.9%±1.2%,heart index was 3.2%±1.4%,2.6%±1.3%,respectively.The difference in stroke volume and stroke volume was not found in different dialysis models.However,stroke volume in patients receiving intermittent dialysis was significantly higher than that in continuous dialysis (P=0.028);mean 3 hours after dialysis (P=0.015) but was not found in patients with intermittent dialysis.Other biochemical markers were analyzed and analyzed.No significant difference was found between the two dialysis modes (P<0.05),and the level of serum endothelin-1 was significantly increased after continuous dialysis.Conclusion We initially demonstrate that there is no significant difference in the use of intermittent and continuous hemodialysis in patients with acute renal hemodynamics for end-stage renal disease with cerebral hemorrhage;continuous dialysis can significantly increase vasoactive peptide levels and the fluid reactivity is low,intermittent dialysis had the effective removal of small molecule toxins advantage.关键词
间歇性透析/连续性透析/终末期肾病/脑出血/血流动力学Key words
Intermittent dialysis/Continuous dialysis/End stage nephropathy/Cerebral hemorrhage/Hemodynamics分类
医药卫生引用本文复制引用
沈元丽,邵海英,陈凯..间歇与连续性透析对终末期肾病合并脑出血患者血流动力学影响的对照研究[J].中国实用神经疾病杂志,2017,20(13):5-8,4.基金项目
河南省科技发展计划(142300410297) （142300410297）
