中国实用神经疾病杂志2017，Vol.20Issue(13)：15-18,4.
S100β和NSE对带状疱疹后神经痛的监测与疗效评估
Evaluation of the efficacy of S100β and NSE in the diagnosis and treatment of postherpetic neuralgia
摘要
Abstract
Objective To investigate the relationship between the changes of serum S100 beta and NSE levels and the occurrence of postherpetic neuralgia and the efficacy of treatment before and after treatment.Methods 60 cases of acute herpes zoster patients and 20 healthy volunteers,analysis of serum S100 and beta NSE level by ELISA,statistics of postherpetic neuralgia incidence;concurrent detection of postherpetic neuralgia in patients with routine drug treatment before and after treatment serum S100 beta and NSE level change.Results 60 cases of herpes zoster patients with HZ pain was 13.3% (8/60);with PHN HZ patients after treatment of serum S100 and beta NSE level(69.88±2.28,41.13±6.39) is not high in patients with HZ PHN(54.86±8.90,32.61±8.11),the difference was statistically significant (P<0.05);PHN disease patients serum S100 beta and NSE levels(107.36±15.09,98.46±18.25) were significantly increased than it's level of after the treatment (66.18±7.09,45.34±5.02),the difference was statistically significant (P<0.05);and the effect of changes of S100 beta and the level of NSE and PHN in the treatment of SF-MPQ scores of the existence of positive correlation (P<0.05).Conclusion the changes of serum S100 and beta NSE level and postherpetic neuralgia incidence before and after treatment and the existence of positive correlation of serum S100,beta and NSE levels can be used in the evaluation of the monitoring and monitoring the treatment effect of PHN PHN.关键词
带状疱疹后神经痛/S100β/NSE/关联性分析Key words
PHN/S100β/NSE/correlation analysis分类
医药卫生引用本文复制引用
曹艳丽,李姣锋,李毅,孙振涛,樊肖冲..S100β和NSE对带状疱疹后神经痛的监测与疗效评估[J].中国实用神经疾病杂志,2017,20(13):15-18,4.基金项目
河南省科技厅科技攻关项目(172102310080) （172102310080）
