华中师范大学学报（自然科学版）2017，Vol.51Issue(4)：465-469,5.DOI:10.19603/j.cnki.1000-1190.2017.04.009
羧甲基壳聚糖纳米胶束的制备与光响应性研究
Preparation and study of photo-responsive nanomicelles based on carboxymethyl chitosan
摘要
Abstract
The intelligent response polymer micelles have attracted much attention as a carrier of drug controlled release system.Light stimulation is of great interest because of its advantages such as high controllability,clean and high efficiency.In this thesis,1-pyrenemethyl succinate (PMS) was prepared by the esterification of 1-pyrenemethanol with succinic anhydride,which was grafted onto the carboxymethyl chitosan backbone to obtain photoresponsive polymer (PMS-g CMCS),which could self-assemble into light responsive polymeric micelles in aqueous condition.The size and morphology of the micelles were characterized and their changes before and after light stimulation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM).Their photoresponsive mechanism was also investigated by fluorescence and 1 H NMR.The results showed that the micelles are spherical-core structures with a diameter of about 200 nm and exhibiteded good storage stability.Under the UV light stimulus,the structure will be able to chang.The photoresponsive mechanism can be attributed to the breakage of ester bond linked to PyM.These properties of micelles show the potential for use as a light controlled release carrier of hydrophobic drug or pesticide.关键词
羧甲基壳聚糖/光响应/纳米胶束Key words
carboxymethyl chitosan/photo responsiveness/nanomicelle分类
化学化工引用本文复制引用
张玲,刘娜,向锐,朱翠婷,刘雅嘉,易英,殷以华..羧甲基壳聚糖纳米胶束的制备与光响应性研究[J].华中师范大学学报（自然科学版）,2017,51(4):465-469,5.基金项目
国家自然科学基金项目(51373130) （51373130）
武汉理工大学本科生创新研究基金(2016-HS-B1-12). （2016-HS-B1-12）
