解放军医学杂志2017，Vol.42Issue(8)：680-685,6.DOI:10.11855/j.issn.0577-7402.2017.08.04
介入超声印压系统对活体舒张心肌黏弹性的检测作用
Detection of the viscoelasticity of relaxed myocardium in vivo by intervention ultrasound indentation system
摘要
Abstract
Objective To explore the viscoelasticity of relaxed myocardium in vivo through indentation method with an intervention ultrasound indentation system (IUIS). Methods Old myocardial infarction (OMI) models of canine were established by ligating left anterior descending branch of coronary artery for 3 months. The indentation creep tests were used respectively in OMI group and shame group (n=8, each) by IUIS in middle and advanced diastole stage in vivo. Test data were processed with three-parameter solid viscoelasticity model, and the viscoelastic parameters, such as instantaneous elastic modulus (E1), relaxation modulus (E∞), creep elastic modulus (E2) and viscous damping coefficient (η) in normal and infarcted myocardium were obtained and compared. Results All the parameters of E1, E∞, E2 and η increased obviously in OMI group than in sham group shown as follows: 27.81±6.74kPa vs. 6.78±2.43kPa; 17.87±3.59kPa vs. 4.52±1.56kPa; 49.54±14.35kPa vs. 16.82±12.37kPa and 1.97±0.78Pa.s vs. 0.66±0.40Pa.s. The differences were statistically significant (P<0.05). Conclusions IUIS is a feasible method to assess the viscoelasticity of relaxed myocardium in vivo. Three-parameter viscoelasticity model can be used to describe creep properties of relaxed myocardium. Both elastic modulus and viscosity resistance have increased in infarcted myocardium.关键词
介入超声印压系统/舒张心肌/印压蠕变实验/三参量黏弹性模型/黏弹性参数Key words
intervention ultrasound indentation system/relaxed myocardium/indentation creep test/three-parameter viscoelastic model/viscoelastic parameters分类
医药卫生引用本文复制引用
李进嵩,张春晓,邓辉胜,袁乔英,江永红,朱悫,黄晶..介入超声印压系统对活体舒张心肌黏弹性的检测作用[J].解放军医学杂志,2017,42(8):680-685,6.基金项目
国家自然科学基金(30371361、30527001) （30371361、30527001）
四川省卫生厅资助项目(110210)This work was supported by the National Natural Science Foundation of China (30371361, 30527001) and the Foundation of Health and Family Planning Commission of Sichuan Province (110210) （110210）
