军事医学2017，Vol.41Issue(6)：424-429,6.DOI:10.7644/j.issn.1674-9960.2017.06.004
T细胞缺陷裸小鼠部分肝切除肝再生异常
Abnormal liver regeneration of T-cell-deficient mice after partial hepatectomy
摘要
Abstract
Objective To investigate the regulation of T cells in the process of liver regeneration using a model of mice after 70% liver resection.Methods We performed 70% hepatectomy in T-cell-deficient mice and control mice.The liver mass and body mass ratio, BrdU infiltration level, proliferating cell nuclear antigen (PCNA),expression of M phase marker protein p-HDAC3, and serum transaminase levels were measured.Results The recovery of liver mass and body mass ratio of thymus-deficient mice occurred significantly later than that of control mice.The peak time of BrdU infiltration levels and the expression of PCNA and p-HDAC3 in T-cell-deficient mice were later than in control mice, but the degree of liver injury was lower.Conclusion T cells are involved in the regulation of liver regeneration, and the absence of T cells delays the process of liver regeneration.关键词
T淋巴细胞/肝切除术/肝再生/基因表达/增殖细胞核抗原/裸小鼠/肝损伤Key words
T-lymphocytes/hepatectomy/liver regeneration/gene expression/proliferating cell nuclear antigen/nude mice/liver injury分类
医药卫生引用本文复制引用
雷达鑫,卜雯婧,刘贤,孟晓竹,陈慧,詹轶群,杨晓明,于淼..T细胞缺陷裸小鼠部分肝切除肝再生异常[J].军事医学,2017,41(6):424-429,6.基金项目
蛋白质组学国家重点实验室合作研究课题(SKLP-K201404)资助 （SKLP-K201404）
