军事医学2017，Vol.41Issue(6)：494-497,4.DOI:10.7644/j.issn.1674-9960.2017.06.019
AKR1C3在放疗食管癌患者病理标本检测中的意义
Significance of AKR1C3 for esophageal cancer patients under radiotherapy
摘要
Abstract
Objective To evaluate the significance of the expression level of aldo-keto reductase family 1 member C3(AKR1C3) for esophageal carcinoma patients treated with radiotherapy.Methods The clinical data of 28 patients with locally advanced esophageal carcinoma treated with radiotherapy alone was retrospectively analyzed, and the expression level of AKR1C3 was detected by immunohistochemistry.Statistical analysis was performed using SAS 8 statistical software, P<0.05 was considered statistically significant difference.Results The expression level of AKR1C3 was different in esophageal carcinoma patients at different levels of differentiation.The level of AKR1C3 expression was negatively correlated with efficacy of radiotherapy (P=0.031, 95%CI 0.151-0.914).Conclusion AKR1C3 can serve as a promising biomarker of the efficacy of radiotherapy for esophageal cancer.关键词
食管肿瘤/放射疗法/AKR1C3Key words
esophageal neoplasms/radiotherapy/AKR1C3分类
医药卫生引用本文复制引用
赵静,熊伟,周德敏,高献书,任军..AKR1C3在放疗食管癌患者病理标本检测中的意义[J].军事医学,2017,41(6):494-497,4.基金项目
国家自然科学基金资助项目(80172017) （80172017）
