检验医学与临床2017，Vol.14Issue(12)：1720-1722,1725,4.DOI:10.3969/j.issn.1672-9455.2017.12.014
NT-proBNP水平对急性心力衰竭患者近期预后的评估价值
Value of NT-proBNP in evaluation of short-term prognosis in patients with acute heart failure
摘要
Abstract
Objective To explore the evaluation value of N terminal brain natriuretic peptide(NT-proBNP) level on the short term prognosis in the patients with acute heart failure.Methods One hundred and twenty-two patients with acute heart failure receiving the therapy in our hospital from January to december 2015 were selected as the research subjects.All cases were treated by the routine therapy and followed up for 30 d.The cases of re-hospitalization due to cardiac shock and death were included in the event group and the other cases were included in the non-event group.The differences in the aspects of general data,clinical manifestations and body signs were compared between the two groups.The multivariate Logistic regression analysis was performed to observe the risk factors influencing the prognosis of the patients.Results Among 122 cases,the terminal event after 30 d follow up occurred in 40 cases.So these 40 cases were included in the event group and 82 cases were included in the non-event group.There were no statistically significant differences in the aspects of age,sex,body mass index,history of hypertension,history of myocardial infarction,coronary heart disease and atrial fibrillation between the two groups(P＞0.05).The cardiac function NYHA grade Ⅲ in the non-event group accounted for 81.71 ％,which was significantly higher than 40.00 ％ in the event group,grade Ⅳ accounted for 18.29％,which was significantly lower than 60.00％ in the event group(P＜0.05).There were no statistically significant differences in the aspects of dyspnea,aortic regurgitation,diastolic pressure and heart rate between the two groups(P＞0.05).The proportions of lower extremity edema,pulmonary rales and mitral regurgitation in the event group were significantly higher than those in the non-event group(P＜0.05).The LVEDD value and NT-proBNP level of the event group were significantly higher than those of the non-event group,while the LVEF value and systolic pressure were significantly lower than those of non-event group(P＜ 0.05).By the Logistic regression analysis,NT-proBNP level too high was a significant independent risk factor for short term adverse prognosis in the patients with acute heart failure (OR =3.522,P=0.021,95 ％ CI was 1.080-4.361).Conclusion Higher NT-proBNP level is a significant risk factor for poor short term prognosis in the patients with acute heart failure.关键词
N末端脑钠肽前体/急性心力衰竭/预后Key words
N terminal brain natriuretic peptide/acute heart failure/prognosis引用本文复制引用
李曼,温冬梅,王伟佳,冯力,杜满兴,徐胜男,徐全中..NT-proBNP水平对急性心力衰竭患者近期预后的评估价值[J].检验医学与临床,2017,14(12):1720-1722,1725,4.基金项目
广东省中山市科技局计划项目(2015B1118). （2015B1118）
