日用化学工业2017，Vol.47Issue(7)：418-420,3.DOI:10.13218/j.cnki.csdc.2017.07.013
高效液相色谱法同时测定化妆品中5种防腐剂
Simultaneous determination of five kinds of preservative in cosmetics by high performance liquid chromatography
张卓娜 1林少彬 1杨艳伟1
作者信息
- 1. 中国疾病预防控制中心环境与健康相关产品安全所,北京 100021
- 折叠
摘要
Abstract
A high performance liquid chromatography method was established for determination of five kinds of preservative in cosmetics.A C18 column (250 mm ×4.6 mm,5 μm)was used as stationary phase,and methanol aqueous solution was used as mobile phase with a flow rate of 1.0 mL/ min.The detection wavelength was set at 230 nm and the column temperature was 25 ℃.The linearity range of the five kinds of preservative is 0 -200 mg/L,and the method shows a good linear relationship.The detection limits for chlorphenesin,biphenyl -2-ol,chloroxylenol,chlorophene and triclosan achieve 0.10,0.10,0.15,0.25 and 0.30 mg/L respectively.The spiked recovery rate varies from 97.6% to 115% .The relative standard deviation achieves 0.30% -1.65% (n=6).关键词
化妆品添加剂/防腐剂/高效液相色谱法Key words
additive of cosmetics/preservative/high performance liquid chromatography分类
化学工程引用本文复制引用
张卓娜,林少彬,杨艳伟..高效液相色谱法同时测定化妆品中5种防腐剂[J].日用化学工业,2017,47(7):418-420,3.
