山东医药2017，Vol.57Issue(28)：77-79,3.DOI:10.3969/j.issn.1002-266X.2017.28.024
非ST段抬高型急性冠脉综合征患者MLR变化及其与冠脉病变程度的关系
Changes of monocyte to lymphocyte ratio and its relationship with severity of coronary artery lesions in patients with non-ST-elevation acute coronary syndrome
樊泽元 1季汉华 1李阳1
作者信息
- 1. 民航总医院 北京大学民航临床医学院,北京100123
- 折叠
摘要
Abstract
Objective To investigate the relationship between monocyte to lymphocyte ratio (MLR) and severity of coronary artery lesion in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS).Methods Based on SYNTAX score, 319 patients with NSTE-ACS were divided into the mild stenosis group (n=152), moderate stenosis group (n=89), and severe stenosis group (n=78).And the non-coronary artery disease group consisted of 237 patients without coronary artery disease.The peripheral venous blood of all patients was collected to measure the counts of monocytes and lymphocytes which were used for the calculation of MLR.Receiver operating characteristic (ROC) curve was utilized to evaluate the diagnostic value of MLR in NSTE-ACS.Liner regression equation was used to analyze the relationship between MLR and severity of coronary artery lesions in patients with NSTE-ACS.Results The MLR levels of the mild stenosis group, moderate stenosis group, and severe stenosis group were higher than that of the non-coronary artery disease group;and MLR gradually increased with the degree of coronary artery lesions (all P<0.01).ROC analysis demonstrated that the areas under curve (AUC) for MLR detecting NSTE-ACS was 0.712 (95% CI:0.636-0.752), and an optimized cut-off point of MLR was 0.23 with a sensitivity and specificity of 68.15% and 63.89%.Linear regression equation analysis showed that MLR was positively correlated with lesion severity (r=0.54, P<0.01).Conclusion The level of MLR is elevated in patients with NSTE-ACS, which is positively correlated with coronary artery severity of NSTE-ACS.关键词
非ST段抬高急性冠脉综合征/单核细胞与淋巴细胞比值/SYNTAX评分Key words
non-ST-elevation acute coronary syndrome/monocyte to lymphocyte ratio/SYNTAX score分类
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樊泽元,季汉华,李阳..非ST段抬高型急性冠脉综合征患者MLR变化及其与冠脉病变程度的关系[J].山东医药,2017,57(28):77-79,3.
