世界中医药2017，Vol.12Issue(6)：1310-1313,1316,5.DOI:10.3969/j.issn.1673-7202.2017.06.023
中晚期非小细胞肺癌患者采用中西医结合疗法的临床治疗效果研究
Therapeutic Effect of Integrated Chinese and Western Medicine in Advanced Non-small Cell Lung Cancer
摘要
Abstract
Objective:To observe the curative effect of chemotherapy combined with traditional Chinese medicine (TCM) in the treatment of advanced non-small cell lung cancer (NSCLC),and to explore the mechanism of the treatment.Methods:Ninety-six patients with advanced non-small cell lung cancer (NSCLC) diagnosed in our hospital from February 2016 to July 2016 were randomly divided into a control group (n =48) and a treatment group (n =48).The patients in the control group were treated with standard chemotherapy.The treatment group was treated with chemotherapy combined with TCM which benefits qi,tonifies yin and eliminates toxity and phlegm.Lesion changes,TCM syndrome score,Karnofsky score,peripheral blood and cytokines (SLR-2R and TNF-α) after 2 courses were selected as the therapeutic indexes of the two groups,and the therapeutic effects were compared between the two groups.Results:For lesion changes,the effective rate of the treatment group (16.67％) was higher than that of the control group (14.58％),but the difference was not statistically significant (x2 =0.079,P =0.779).The stability rate of the treatment group (81.25 ％) was higher than that of the control group (60.42％),and the difference was statistically significant (x2 =5.042,P =0.025).For TCM syndrome score,the improvement rate of treatment group(87.50％) was higher than that of the control group(60.42％),and the difference was statistically significant(x2 =21.542,P =0.000);for Karnofsky score,the increasing stability rate of the treatment group (72.92％) was higher than that of the control group (40.00％),and the difference was statistically significant(x2 =32.928,P =0.000);for peripheral blood change,the bone marrow suppression ratio of the treatment group (10.42％) was lower than that of the control group (50.00％),and the difference was statistically significant (x2 =37.152,P =0.000);for changes of cytokine SLR-2R and TNF-α,the situation of treatment group was better than that of the control group,and the difference was statistically significant (t =3.956,P =0.000;t =3.797,P =0.000).Conclusion:The combined use of TCM and chemotherapy can better control the lesion condition,relieve patient's condition and enhance the treatment effect in advanced non-small cell lung cancer than treating with chemotherapy alone.It is worthy to be popularized in clinic.关键词
非小细胞肺癌/益气养阴化痰毒/中西医结合/临床疗效Key words
Non-small cell lung cancer/Benefits qi, tonifies yin and eliminates toxity and phlegm/Integrative Chinese and western medicine/Clinical efficacy分类
医药卫生引用本文复制引用
王煜坤,冯桂阳..中晚期非小细胞肺癌患者采用中西医结合疗法的临床治疗效果研究[J].世界中医药,2017,12(6):1310-1313,1316,5.基金项目
河南省卫生厅2013年卫生政策研究课题(编号:YWZY201311) （编号:YWZY201311）
