生命科学研究2017，Vol.21Issue(3)：257-261,5.DOI:10.16605/j.cnki.1007-7847.2017.03.012
WRAP53β的分子功能及其在疾病中的作用
Molecular Function of WRAP53β and Its Role in Diseases
摘要
Abstract
The WRAP53β protein,an important member of the WD40 protein family,controls intracellular trafficking of telomerase,DNA repair proteins and the splicing factors,and is also involved in the formation of Cajal body,telomere stability and elongation.Dysfunction of this protein has been associated with premature aging,cancer and neurodegeneration,and this suggests that WRAP53β will be a potential molecular target in treatment of diseases.Here,the multifaceted molecular functions of WRAP5β and its research progress in diseases were reviewed.关键词
WRAP53β/卡哈尔体/DNA双链断裂/端粒酶/肿瘤Key words
WRAP5β/Cajal body/DNA double-strand break/telomerase/neoplasms分类
生物科学引用本文复制引用
陈洁莹,孙洋,杨潮,李江林,叶茂..WRAP53β的分子功能及其在疾病中的作用[J].生命科学研究,2017,21(3):257-261,5.基金项目
国家重点基础研究发展计划“973项目”(2013CB932702) （2013CB932702）
国家自然科学基金资助项目(81272220,81402304,81672760) （81272220,81402304,81672760）
湖南省自然科学基金资助项目(2016JJ3048) （2016JJ3048）
