生命科学研究2017，Vol.21Issue(3)：262-267,6.DOI:10.16605/j.cnki.1007-7847.2017.03.013
ELF5在正常乳腺发育和乳腺肿瘤发生中的作用
Effect of ELF5 in Development of Normal Breast and Breast Cancer
摘要
Abstract
E74-like factor 5 (ELF5),also known as ESE2,is a member of the E-twenty-six (ETS) family and plays an important role in regulating the development of embryonic and breast tissues.It has a critical effect on embryonic formation of the inner cell mass or the cell fate determination during embryonic morula.In normal breast development,ELF5 can induce the directional differentiation of the mammary gland stem/progenitor cells into mammary gland secretion cell types during pregnancy.However,ELF5 is a key transcriptional factor that can not only induce mammary gland tumor cell transformation from the luminal subtypes to basal-like subtypes,but also inhibit cell phenotype towards estrogen sensitivity in breast cancer.Here,the characteristics of the ELF5 transcriptional factor in its structure,biological functions and the effect on the development of mammary gland in mammals are introduced.关键词
ELF5/乳腺肿瘤于细胞/胚胎发育/乳腺癌/细胞命运Key words
E74-like factor 5 (ELF5)/breast cancer stem cells/embryonic development/breast cancer/cell fate分类
生物科学引用本文复制引用
苏启明,曲鑫建,伍会健..ELF5在正常乳腺发育和乳腺肿瘤发生中的作用[J].生命科学研究,2017,21(3):262-267,6.基金项目
国家自然科学基金(31171353) （31171353）
中央高校基本科研业务费专项资金资助项目(DUT16QY28,DUT14RC(3)022) （DUT16QY28,DUT14RC(3）
