生命科学研究2017，Vol.21Issue(3)：275-282,8.DOI:10.16605/j.cnki.1007-7847.2017.03.015
乳腺癌靶向治疗的研究进展
Progresses on Targeted Therapy for Human Breast Cancer
摘要
Abstract
Breast cancer is one of the most common cancers that lead to death in women worldwide.At present,chemotherapy is still an important means of systemic treatment of breast cancer besides the surgical treatment.But poor prognosis,short survival and fast recurrence affect the therapeutic effect.With the development of the signaling pathways and cell apoptosis in the tumor research,targeted therapy against main signaling pathways of breast carcinogenesis has become a focus of anti-tumor research,and some progress has been made in the treatment of breast cancer.In recent years,studies found that acetylcholine receptors are correlated with the occurrence and development of many diseases,especially tumors.Therefore,alphaconotoxins,as a specific antagonist of the acetylcholine receptor,may become a novel targeted therapy drug for breast cancer.关键词
乳腺癌/发病机理/靶向治疗/芋螺毒素/烟碱型乙酰胆碱受体(nAChRs)Key words
breast cancer/pathogenesis/targeted therapy/conotoxins/nicotinic acetylcholine receptors (nAChRs)分类
医药卫生引用本文复制引用
孙志华,邴晖,刘益巧,钱江,长孙东亭,罗素兰..乳腺癌靶向治疗的研究进展[J].生命科学研究,2017,21(3):275-282,8.基金项目
国家自然科学基金资助项目(81420108028) （81420108028）
长江学者和创新团队发展计划(IRT_15R15) （IRT_15R15）
海南省普通高等学校研究生创新科研课题(Hyb2016-08) （Hyb2016-08）
