实用妇产科杂志2017，Vol.33Issue(6)：430-434,5.
不同女性人群生殖道人乳头瘤病毒感染状况分析
Investigation and Analysis on HPV Infection Status of Different Female Groups
摘要
Abstract
Objective:To investigate HPV(human papillomavirus) infection status of different female groups for providing theoretical basis of developing screening programs in them.Methods:The infection status of HPV in 3376 women of gynecology department were examined with gene chip technique in Chongqing Obstetrics and Gynecology Hospital from Jan 2010 to Dec 2015.All the women were divided into 5 groups:Ordinary groups(770 cases),gynecological patients groups (1069 cases),CI N groups (560 cases),infertility g rou ps (648 cases),puerperium groups(329 cases).The infection status of various subtypes of HPV was compared and analyzed.Results:①Out of the 22 subtypes of HPV,HPV6 (14.81％,500/3376)was most conmen of all types,followed by subtypes HPV16 (14.16％,478/3376),HPV52 (12.59％,425/3376),HPV58 (11.91％,402/3376),HPV43 (6.66％,225/3376),and there were no HPV44.②The HPV positive rate and the HR-HPV(high risk HPV)positive rate were all different in the 5 groups which were CIN groups(89.46％,501/560;85.89％,481/560),infertility groups (66.67％,432/648;58.80％,381/648),gynecological patients groups (62.77％,671/1069;55.57％,594/1069),ordinary groups (24.03％,185/770;19.22％,148/770,puerperium groups (13.07％,43/329;10.03％,33/329)by descending order.③)Subtype of HPV DNA was different in different groups of people,subtypes of HR-HPV were found out more in CIN groups and infertility groups,and the subtypes of HPV were similar in them while the most frequent subtypes were HPV16/58/52,and the rate of multi-infection of HPV in CIN groups and infertility groups was higher than that of the other groups(P ＜ 0.01).But,the rate of HR-HPV infection and multi-infection in gynecological department was obviously higher than that of puerperium groups and normal people.④The positive rate of HPV/HR-HPV in CIN were increasing with the increase of clinical stage （x2HPV =57.49,P＜0.01;x2hr-hpv =58.40,P＜0.01).There were more HPV mixed infection cases in CIN Ⅱ/Ⅲ with three types and above than that in CIN Ⅰ (x2 =8.96,P ＜ 0.05).The positive rate of HPV16 in CIN Ⅱ / Ⅲ was higher than that in CIN Ⅰ[(x2 =33.24,P ＜0.01).Conclusions:Woman who is infertile or with gynecological disease has high risk of HPV infecting and CIN.Pay attention to opportunistic screening is an effective measures for improving the CIN detection rate,the HPV infection status of different female groups is different obviously.Specific screening programs should be developed for different female groups in the future.关键词
人乳头瘤病毒/宫颈癌/宫颈上皮内瘤变/不孕症/产褥期Key words
Human papillomavirus/Cervical cancer/Cervical intraepithelial neoplasia/Infertility/Puerperium分类
医药卫生引用本文复制引用
杨君,周德平,龙馨,吕江涛,但阳..不同女性人群生殖道人乳头瘤病毒感染状况分析[J].实用妇产科杂志,2017,33(6):430-434,5.基金项目
重庆市卫计委重点项目(编号:2013-1-043) （编号:2013-1-043）
