实用肿瘤杂志2017，Vol.32Issue(4)：312-318,7.
LZTS1的表达与乳腺癌化疗药物敏感性关系的研究
Association between the expression of LZTS1 and the chemosensitivity of breast cancer
摘要
Abstract
Objective To investigate the relationship between leucine zipper tumor suppressor 1 (LZTS1 )and breast cancer chemosensitivity.Methods Collagen gel droplet-embedded culture-drug sensitivity test (CD-DST)was per-formed for 122 cases of breast cancer surgery samples,and the relationship between the expression of LZTS1 and cancer chemosensitivity was analyzed.The protein expression of LZTS1 in 278 biopsy samples of breast cancer after neoadjuvant chemotherapy was examined by immunohistochemical assay.The relationship between LZTS1 expression and chemotherapy response was further analyzed.Results The expression of LZTS1 in breast cancer patients was positively related to the sensitivity of paclitaxel and vinorelbine (r =0.311,r =0.206;both P <0.05),but was not significantly related to the sensi-tivity of epirubicin,5-fluorouracil and cisplatin(r =0.121,r =0.083,r =0.010;all P >0.05).Logistic regression analysis suggested that LZTS1 expression can predict the complete response rates of breast cancer patients after treatments of paclita-xel-based chemotherapies,including paclitaxel +doxorubicin,paclitaxel +epirubicin and paclitaxel +epirubicin +cyclophos-phamide(P <0.01).Conclusion LZTS1 may be used as a marker to predict the response of breast cancer to paclitaxel-based chemotherapy.关键词
乳腺肿瘤/LZTS1/化疗药物敏感性/紫杉醇/长春瑞滨Key words
breast neoplasms/LZTS1/chemosensitivity/paclitaxel/vinorelbine分类
医药卫生引用本文复制引用
李伟东,王淑玲,郝春芳,付丽..LZTS1的表达与乳腺癌化疗药物敏感性关系的研究[J].实用肿瘤杂志,2017,32(4):312-318,7.基金项目
国家自然科学基金(81602340,81672637) （81602340,81672637）
院级引进人才与博士启动基金项目(B1311,B1217) （B1311,B1217）
