武汉工程大学学报2017，Vol.39Issue(4)：320-325,6.DOI:10.3969/j.issn.1674⁃2869.2017.04.003
壳聚糖衍生物手性固定相的制备及其分离性能
Preparation and Enantioseparation Performance of Chiral Stationary Phases Derived from Chitosan Derivatives
摘要
Abstract
To develop new materials for enantioseparation,chitosan bis(3,5-dimethylphenylcarbamate)-(benzamide) and chitosan bis(4-methylphenylcarbamate)-(benzamide) were prepared. With regard to the benzoylation of chitosan,the complete benzoylation was achieved when benzoic anhydride was fed at six equivalences of the glucosamine. The two chitosan derivatives were coated on the surface of aminopropyl silica gel,then the corresponding chiral stationary phases were obtained. The enantioseparation performance of the two chiral stationary phases was evaluated with 12 chiral compounds by high performance liquid chromatography in the mobile phases of n-hexane/isopropanol,n-hexane/ethanol and n-hexane/methanol/ethanol. The results show that the chiral stationary phases possess good chiral recognition capability towards the analytes. Meanwhile,the influence of the composition of the mobile phase on enantioseparation was discussed according to the separation results.关键词
壳聚糖/苯甲酰化/手性分离材料/高效液相色谱/手性识别Key words
chitosan/benzoylation/chiral separation material/high performance liquid chromatography/chiral recognition分类
化学化工引用本文复制引用
梁爽,宾琴,柏正武,陈伟..壳聚糖衍生物手性固定相的制备及其分离性能[J].武汉工程大学学报,2017,39(4):320-325,6.基金项目
国家自然科学基金(51373127) （51373127）
