西安交通大学学报（医学版）2017，Vol.38Issue(4)：517-521,5.DOI:10.7652/jdyxb201704010
铁碳纳米粒介导顺铂对肺癌细胞化疗敏感性的影响
Effects of carbon-coated iron nanoparticles carrying cisplatin on the chemotherapy sensitivity of lung cancer cells
摘要
Abstract
Objective To investigate the inhibitory effect of carbon-coated iron nanoparticles carrying cisplatin on the growth of NCI-H446 lung cancer cells and expressions of Caspase 3 and Survivin mRNA.Methods NCI-H446 lung cancer cells were treated with iron-carbon nanoparticles and/or cisplatin.The cell viability was detected by MTT method,and the mRNA expressions of Caspase 3 and Survivin were measured with RT-PCR.Results Cisplatin could inhibit the growth of NCI-H446 lung cancer cells,and the inhibitory effect was stronger when it was combined with the iron-carbon nanoparticles.The cells had apoptosis.The mRNA expression of Caspase 3 of NCI-H446 lung cancer cells was remarkably enhanced after treatment with iron-carbon nanoparticles combined with cisplatin,while the mRNA expression of Survivin was notably weakened (P＜0.05).Conclusion Carbon-coated iron nanoparticles carrying cisplatin could significantly increase the chemotherapy sensitivity of cisplatin on NCI-H446 lung cancer cells and enhance the therapeutic efficacy of chemotherapy drugs.关键词
铁碳纳米粒/顺铂/肺癌/Caspase 3/SurvivinKey words
carbon-coated iron nanoparticle/cisplatin/lung cancer/Caspase 3/Survivin分类
医药卫生引用本文复制引用
党晓敏,孙忠民,杨岚,尚东,钟徽,胡浩,郭建新..铁碳纳米粒介导顺铂对肺癌细胞化疗敏感性的影响[J].西安交通大学学报（医学版）,2017,38(4):517-521,5.基金项目
中央高校基本科研业务费专项资金资助项目(No.10698201358) Supported by the Fundamental Research Funds for the Central Universities (No.10698201358) （No.10698201358）
