西安交通大学学报（医学版）2017，Vol.38Issue(4)：564-568,5.DOI:10.7652/jdyxb201704019
乙型肝炎病毒对不同ALT状态下慢性乙型肝炎患者肝功和肝纤维化以及肝脏病理分期的影响
Effects of hepatitis B virus on liver function, liver fibrosis and liver pathological staging at different ALT stages
摘要
Abstract
Objective To evaluate the effects of hepatitis B virus on liver function,liver fibrosis,and liver pathological staging at different immune stages.Methods We made a retrospective analysis of 657 patients with chronic hepatitis B diagnosed in the First Hospital of Lanzhou University.Their liver function parameters,liver fibrosis parameters,and hepatitis B virus load were measured by automatic biochemical analyzer,automatic gammaradiation immunity analyzer,and quantitative PCR analyzer,respectively.Effects of hepatitis B virus on liver function,liver fibrosis in different immune stages were analyzed by variance analysis.Effects of hepatitis B virus on liver pathological staging at different immune stages were analyzed by linear trend chi square test analysis.Results In ALT normal chronic hepatitis B patients group,viral load had mild effects on liver function and liver fibrosis parameters.However,in ALT abnormal chronic hepatitis B patients group,viral load had a significant effect on liver function and liver fibrosis parameters,and the effect was most obvious in ALT＞double upper limit of normal group.The specific manifestation was that with viral load increasing,liver function parameters including ALT,AST,TBiL,DBiL,and IBiL increased,while TP and ALB decreased.Liver fibrosis parameters HA,LN,PcⅢ,and CIV all increased (P＜0.05).In ALT normal chronic hepatitis B patients group,viral load had no relationship with liver pathological staging.However,in ALT abnormal chronic hepatitis B patients group,especially ALT≥double upper limit of normal group,viral load was significantly related to liver pathological staging.Conclusion The effects of hepatitis B virus on patients' liver function at different immune stages were different,thus providing evidence-based medicine support for clinical antiviral treatment.关键词
慢性乙型肝炎/病毒载量/肝功能/肝纤维化/肝脏病理分期Key words
chronic hepatitis B/virus load/liver function/liver fibrosis/pathological staging of liver分类
医药卫生引用本文复制引用
高鹏,李俊峰,周伟,杨彦麟,毛小荣,陈琳,岳伟,张立婷..乙型肝炎病毒对不同ALT状态下慢性乙型肝炎患者肝功和肝纤维化以及肝脏病理分期的影响[J].西安交通大学学报（医学版）,2017,38(4):564-568,5.基金项目
兰州大学第一医院院内基金资助(ldyyyn2014-14) Supported by the First Hospital of Lanzhou University Foundation (ldyyyn2014-14) （ldyyyn2014-14）
