畜牧兽医学报2017，Vol.48Issue(7)：1181-1190,10.DOI:10.11843/j.issn.0366-6964.2017.07.002
尾分析法在不同规模群体中开展全基因组关联研究
A Genome-wide Association Study of Different Size Populations Based on Tail Analysis
摘要
Abstract
Tail analysis and genome-wide association studies(GWAS) were combined in this study to determine preliminary two tails selection criterions.A total of 2 000,1 500,1 000 and 500 samples and 20％,15％,12％,10％,8％,5％ of two tails were used to run GWAS to estimate the effects of the population size on GWAS and the effect of the proportion of two tails on GWAS,respectively.The results showed that the number of significant SNPs decreased with the reducing population size and the proportion of two tails.The preliminary selection criterions were:traits with heritability of about 0.38,the proportion of two tails of 8％,10％,10％ and 20％ from 2 000,1 500,1 000 and 500 samples,which were appropriate for two tails population for running GWAS,respectively.Further,the traits with heritability of about 0.50,the proportion of two tails of 5 ％,5％,10％ and 15％ from 2 000,1 500,1 000 and 500 samples were appropriate for two tails population for running GWAS,respectively.The present preliminary two tails selection criterions from populations with various sizes to run GWAS could detect significant SNPs effectively and also provide a strategy of reducing the cost of GWAS.关键词
尾分析法/全基因组关联分析/遗传力/选择比例Key words
tail analysis/genome-wide association study/heritability/selection proportion分类
农业科技引用本文复制引用
武群清,张龙超,黄生强,王立贤..尾分析法在不同规模群体中开展全基因组关联研究[J].畜牧兽医学报,2017,48(7):1181-1190,10.基金项目
国家科技支撑计划项目(2015BAD03B02-2) （2015BAD03B02-2）
中国农业科学院科技创新工程(ASTIP-IAS02) （ASTIP-IAS02）
国家生猪产业技术体系(CARS-36) （CARS-36）
