烟草科技2017，Vol.50Issue(7)：57-61,5.
葛花对缓解小鼠急性酒精中毒的影响
Alleviation effect of Puerariae flos on acute alcoholism in mice
摘要
Abstract
In order to investigate the alleviation effect and mechanism of Puerariae flos on acute alcoholism, a test cigarette was prepared by adding a certain amount of Puerariae flos into cut tobacco. According to the fumigation therapy theory and action mode of traditional Chinese medicines, experimental mice were treated by treatment 1 (gastric lavage with alcohol + mainstream cigarette smoke exposure) and treatment 2 (mainstream cigarette smoke exposure + gastric lavage with alcohol) separately, then the antialcoholism effects and the variations of alcohol concentration in blood and alcohol dehydrogenase activity in liver of mice were investigated. The results showed that: 1) Comparing with control groups, the drunkenness time of treatment 1 group significantly reduced when a high dosage of Puerariae flos was added into cigarette; for treatment 2 group, alcohol tolerance time remarkably increased, while drunkenness time decreased with the increase of Puerariae flos adding rate. 2) Increasing Puerariae flos adding rate raised the alcohol dehydrogenase activity in liver, while decreased the alcohol concentration in blood obviously along with the proceeding of time. Mainstream smoke of cigarette pretreated by adding Puerariae flos into cut tobacco has an obvious alleviation effect on acute alcoholism in mice.关键词
烟熏疗法/葛花/血醇浓度/乙醇脱氢酶Key words
Fumigation therapy/Puerariae flos/Blood alcohol concentration/Alcohol dehydrogenase (ADH)分类
轻工纺织引用本文复制引用
黄菲,潘晓薇,周瑢,陶红,陆一鸣..葛花对缓解小鼠急性酒精中毒的影响[J].烟草科技,2017,50(7):57-61,5.基金项目
广东中烟工业有限责任公司科技项目"中草药解酒复方的作用及其在卷烟中的效果评价研究"(粤烟工[2013]科字第02号). （粤烟工[2013]科字第02号）
