烟草科技2017，Vol.50Issue(7)：62-68,7.
成瘾剂量下烟碱对大鼠的毒性损伤
Nicotine toxicity to rats at addictive dosage
摘要
Abstract
To study the toxicity of nicotine at addictive dosage using rats as a model, SD rats were injected with nicotine subcutaneously, meanwhile the nicotine-dependence model of rat was established by using CPP apparatus, and the variation of initial nicotine-dependence duration was investigated successively. The blood count parameters, blood biochemistry and histopathology of each organ of nicotine-dependent rat were studied. The results showed that: 1) 0.2 mg/kg nicotine induced stable nicotine-dependence in rats after five dosing periods, and the degree of nicotine dependence increased first and then decreased to the level at the initial stage of addiction. 2) The results of blood count parameters and blood biochemistry indicated that nicotine down-regulated the expression of inflammatory index EOS and up-regulated the levels of liver damage-related GGT and TBIL. 3) Histopathology results indicated that nicotine caused mild edema of liver and kidney in rats, the distinct pathological damage of lung was mainly inflammatory injury. Therefore, nicotine had mild toxicity for rats at nicotine-dependence dosage (0.2 mg/kg), the lung, liver and immune system of rats suffered different degrees of toxic damage due to nicotine.关键词
烟碱/皮下注射/成瘾模型/毒性损伤Key words
Nicotine/Subcutaneous injection/Nicotine-dependence model/Toxicity分类
轻工纺织引用本文复制引用
朱欣潮,陈欢,胡香杰,任秀花,王安,刘勇,侯宏卫,胡清源..成瘾剂量下烟碱对大鼠的毒性损伤[J].烟草科技,2017,50(7):62-68,7.基金项目
国家烟草专卖局重点项目"烟碱致瘾性阈值研究"(110201402037) （110201402037）
国家烟草质量监督检验中心科技创新项目"电子烟主成分气溶胶吸入暴露毒性研究"(552015CQ0060). （552015CQ0060）
